Amitiza and Enulose drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitiza (lubiprostone) and Enulose (lactulose). Common drug interactions include bronchitis chronic among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Amitiza and Enulose. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

What is Enulose?

Enulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 711 Enulose users. Check the latest studies of Enulose.

On Jul, 16, 2026

13 people who take Amitiza and Enulose together, and have interactions are studied.

What are the common drug interactions of Amitiza and Enulose, by gender? *:

female:

Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Carotid artery stenosis (narrowing of carotid artery)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Foot fracture
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Lung disorder (lung disease)
Malaise (a feeling of general discomfort or uneasiness)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Memory impairment

male:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

What are the common drug interactions of Amitiza and Enulose, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaemia (lack of blood)
Anxiety
Arthralgia (joint pain)
Ataxia (loss of full control of bodily movements)
Back pain
Candidiasis (candidiasis or thrush is a fungal infection)
Cerebellar syndrome (impaired blood circulation to cerebellum due to lesion in artery)
Colitis (inflammation of colon)
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Contusion (a type of hematoma of tissue in which capillaries)

50-59:

Abdominal pain
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Carotid artery stenosis (narrowing of carotid artery)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dyspnoea (difficult or laboured respiration)
Foot fracture
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Headache (pain in head)
Lung disorder (lung disease)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)

60+:

Nausea (feeling of having an urge to vomit)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Heart rate increased
Muscle rupture (tear in muscle)
Urinary tract infection bacterial
Malaise (a feeling of general discomfort or uneasiness)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Blood pressure increased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 6 people, 46.15%
Nausea And Vomiting: 6 people, 46.15%
Pain: 6 people, 46.15%
Neuralgia (pain in one or more nerves): 4 people, 30.77%
High Blood Cholesterol: 4 people, 30.77%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 30.77%
Insomnia (sleeplessness): 4 people, 30.77%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 30.77%
Stress And Anxiety: 4 people, 30.77%
Depression: 4 people, 30.77%

* Approximation only. Some reports may have incomplete information.

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