Amitriptyline hydrochloride and Ritalin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitriptyline hydrochloride (amitriptyline hydrochloride) and Ritalin (methylphenidate hydrochloride). Common drug interactions include cellulitis among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Amitriptyline hydrochloride and Ritalin. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 20,054 Amitriptyline hydrochloride users. Check the latest studies of Amitriptyline hydrochloride.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.

On Jul, 12, 2026

54 people who take Amitriptyline hydrochloride and Ritalin together, and have interactions are studied.

Amitriptyline hydrochloride and Ritalin drug interactions.

What are the common drug interactions of Amitriptyline Hydrochloride and Ritalin, by gender? *:

female:

Cellulitis (infection under the skin)
Disability
Headache (pain in head)
Neuropathy peripheral (surface nerve damage)
Urinary tract infection
Neuralgia (pain in one or more nerves)
Bone disorder
Chest pain
Dental caries
Drug ineffective

male:

Anxiety
Asthenia (weakness)
Agitation (state of anxiety or nervous excitement)
Restlessness (not able to rest)
Weight decreased
Alanine aminotransferase decreased
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back pain
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)

What are the common drug interactions of Amitriptyline Hydrochloride and Ritalin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abnormal behaviour
Agitation (state of anxiety or nervous excitement)
Asthma
Bipolar disorder (mood disorder)
Decreased appetite
Disturbance in attention
Drug ineffective
Logorrhoea (excessive, uncontrollable, or incoherent talkativeness)
Nail picking
Onychophagia (habit of compulsive nail biting)

20-29:

n/a

30-39:

Anxiety
Nausea (feeling of having an urge to vomit)
Bone disorder
Dental caries
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Lung neoplasm (tumour of lung)
Neuropathy peripheral (surface nerve damage)
Neutropenia (an abnormally low number of neutrophils)
Osteomyelitis (infection of bone)

40-49:

Abscess oral (abscess in the mouth)
Cellulitis (infection under the skin)
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
Substance abuse
Fatigue (feeling of tiredness)
Gastric bypass
Infusion site discomfort
Infusion site induration
Infusion site swelling
Sinusitis (inflammation of sinus)

50-59:

Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Haematuria (presence of blood in urine)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Ageusia (loss of taste functions of the tongue)
Anxiety
Arterial haemorrhage
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back disorder
Balance disorder

60+:

Anxiety
Asthenia (weakness)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back pain
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Blood glucose decreased
Blood pressure fluctuation
Blood urea increased
Bone disorder

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 25 people, 46.30%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 20 people, 37.04%
Drowsiness: 10 people, 18.52%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 16.67%
Metastases To Bone (cancer spreads to bone): 6 people, 11.11%
Prostate Cancer: 5 people, 9.26%
Ill-Defined Disorder: 3 people, 5.56%
Breast Cancer: 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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