Amoxicillin and Actoplus met drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amoxicillin (amoxicillin) and Actoplus met (metformin hydrochloride; pioglitazone hydrochloride). Common drug interactions include adrenal insufficiency among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Amoxicillin and Actoplus met. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Amoxicillin?

Amoxicillin has active ingredients of amoxicillin. It is often used in infection. eHealthMe is studying from 99,235 Amoxicillin users. Check the latest studies of Amoxicillin.

What is Actoplus met?

Actoplus met has active ingredients of metformin hydrochloride; pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 1,210 Actoplus met users. Check the latest studies of Actoplus met.

On Jul, 20, 2026

18 people who take Amoxicillin and Actoplus met together, and have interactions are studied.

Amoxicillin and Actoplus met drug interactions.

What are the common drug interactions of Amoxicillin and Actoplus Met, by gender? *:

female:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Urinary tract infection
Vascular calcification (deposits of calcium in the blood vessels)
Weight decreased
Carotid arteriosclerosis (plaque deposition in artery)
Chills (felling of cold)
Adrenal suppression (suppression of cortisol secretion by the adrenal glands)
Anaemia (lack of blood)
Anaemia of malignant disease
Anxiety

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephropathy (damage to or disease of a kidney)

What are the common drug interactions of Amoxicillin and Actoplus Met, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Skin mass
Swelling face
Nephrogenic anaemia (anaemia due to kidney disease)
Renal impairment (severely reduced kidney function)
Death
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypoaesthesia (reduced sense of touch or sensation)
Nephropathy (damage to or disease of a kidney)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 61.11%
Pain: 10 people, 55.56%
High Blood Pressure: 8 people, 44.44%
High Blood Cholesterol: 7 people, 38.89%
Stress And Anxiety: 4 people, 22.22%
Headache (pain in head): 3 people, 16.67%
Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 16.67%
Cardiac Disorder: 3 people, 16.67%
Erection Problems: 2 people, 11.11%
Gout (uric acid crystals building up in the body): 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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