Amoxicillin and Periogard drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amoxicillin (amoxicillin) and Periogard (chlorhexidine gluconate). Common drug interactions include hypoaesthesia among females and osteonecrosis of jaw among males.

The phase IV clinical study analyzes what interactions people have when they take Amoxicillin and Periogard. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Amoxicillin?

Amoxicillin has active ingredients of amoxicillin. It is often used in infection. eHealthMe is studying from 99,235 Amoxicillin users. Check the latest studies of Amoxicillin.

What is Periogard?

Periogard has active ingredients of chlorhexidine gluconate. eHealthMe is studying from 3,814 Periogard users. Check the latest studies of Periogard.

On Jul, 14, 2026

65 people who take Amoxicillin and Periogard together, and have interactions are studied.

Amoxicillin and Periogard drug interactions.

What are the common drug interactions of Amoxicillin and Periogard, by gender? *:

female:

Hypoaesthesia (reduced sense of touch or sensation)
Osteomyelitis (infection of bone)
Bone disorder
Neck pain
Anxiety
Arthralgia (joint pain)
Spinal osteoarthritis (joint cartilage loss in spine)
Antinuclear antibody positive
Injury
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)

male:

Osteonecrosis of jaw (death of bone of jaw)
Anaemia (lack of blood)
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Exposed bone in jaw
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypoaesthesia (reduced sense of touch or sensation)
Intervertebral disc protrusion (spinal disc protrusion)
Mastication disorder (disease of chewing food)

What are the common drug interactions of Amoxicillin and Periogard, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Actinic keratosis (skin disease due to sun exposure)
Adenomyosis (presence of ectopic glandular tissue found in muscle)
Anaemia (lack of blood)
Anxiety
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Balance disorder
Bone density increased
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Calcinosis (calcium deposits in any soft tissue)

20-29:

n/a

30-39:

n/a

40-49:

Pain
Arthropathy
Hypoaesthesia (reduced sense of touch or sensation)
Injury
Neoplasm malignant (cancer tumour)
Impaired healing
Pneumonia
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Antinuclear antibody positive

50-59:

Stomatitis (inflammation of mucous membrane of mouth)
Abscess oral (abscess in the mouth)
Antinuclear antibody positive
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone marrow failure
Dental discomfort
Fat tissue increased
Foot fracture
Mouth ulceration (mouth ulcers)
Muscle spasms (muscle contraction)

60+:

Osteomyelitis (infection of bone)
Osteonecrosis of jaw (death of bone of jaw)
Loose tooth
Osteoradionecrosis (irradiation of bones causes damage to osteocytes and impairs the blood supply)
Pain
Photopsia (presence of perceived flashes of light)
Posterior capsule opacification
Skin papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections)
Tooth disorder (tooth disease)
Visual acuity reduced (reduced clearness of vision)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 20 people, 30.77%
Multiple Myeloma (cancer of the plasma cells): 19 people, 29.23%
Breast Cancer: 14 people, 21.54%
Metastases To Bone (cancer spreads to bone): 12 people, 18.46%
Bone Cancer Metastatic: 12 people, 18.46%
Osteomyelitis (infection of bone): 4 people, 6.15%

* Approximation only. Some reports may have incomplete information.

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