Amrix and Simvastatin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amrix (cyclobenzaprine hydrochloride) and Simvastatin (simvastatin). Common drug interactions include asthenia among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Amrix and Simvastatin. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Amrix?

Amrix has active ingredients of cyclobenzaprine hydrochloride. It is often used in back pain. eHealthMe is studying from 1,130 Amrix users. Check the latest studies of Amrix.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,969 Simvastatin users. Check the latest studies of Simvastatin.

On Jul, 15, 2026

41 people who take Amrix and Simvastatin together, and have interactions are studied.

Amrix and Simvastatin drug interactions.

What are the common drug interactions of Amrix and Simvastatin, by gender? *:

female:

Asthenia (weakness)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Fall
Fatigue (feeling of tiredness)
Heart rate irregular
Injury
Pain
Social problem
Speech disorder
Agitation (state of anxiety or nervous excitement)

male:

Confusional state
Fatigue (feeling of tiredness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)
Cellulitis (infection under the skin)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fall

What are the common drug interactions of Amrix and Simvastatin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Neuropathy peripheral (surface nerve damage)
Type 2 diabetes mellitus
Blood glucose increased
Cardiac disorder
Coronary artery bypass
Diabetic coma
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hyperglycaemia (high blood sugar)
Organic erectile dysfunction (inability to achieve or maintain an erection long enough to engage in sexual intercourse)

50-59:

Cellulitis (infection under the skin)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Confusional state
Fall
Foot amputation (loss of foot)
Gangrene (body tissue dies)
Impetigo (contagious skin infection)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Necrosis (the death of body tissue)
Skin ulcer

60+:

Depression
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aphasia (damage to the parts of the brain that control language)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Blindness
Cardiomegaly (increased size of heart than normal)
Diarrhoea
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 21.95%
High Blood Pressure: 9 people, 21.95%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 19.51%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 12.20%
Hypersensitivity: 5 people, 12.20%
Infection: 4 people, 9.76%
Diabetes: 4 people, 9.76%
Pain: 4 people, 9.76%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 9.76%
Insomnia (sleeplessness): 4 people, 9.76%

* Approximation only. Some reports may have incomplete information.

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