Ancef and Naproxen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ancef (cefazolin sodium) and Naproxen (naproxen). Common drug interactions include anhedonia among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Ancef and Naproxen. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Ancef?

Ancef has active ingredients of cefazolin sodium. eHealthMe is studying from 3,292 Ancef users. Check the latest studies of Ancef.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,033 Naproxen users. Check the latest studies of Naproxen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

75 people who take Ancef and Naproxen together, and have interactions are studied.

What are the common drug interactions of Ancef and Naproxen, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Injury
Oedema peripheral (superficial swelling)
Pneumonia
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiomegaly (increased size of heart than normal)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis of jaw (death of bone of jaw)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)

male:

Anxiety
Injury
Death
Haemorrhage (bleeding)
Nerve injury
Neuralgia (pain in one or more nerves)
Cellulitis (infection under the skin)
Fatigue (feeling of tiredness)
Depression
Abdominal pain

What are the common drug interactions of Ancef and Naproxen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pneumonia
Cholecystitis chronic (long lasting infection of gallbladder)
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)

30-39:

Chronic kidney disease
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Eyelid oedema (eyelids are swollen and contain excessive fluid)
Hypersensitivity
Syncope (loss of consciousness with an inability to maintain postural tone)

40-49:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Drug ineffective
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure (kidney dysfunction)
Abdominal discomfort
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ankylosing spondylitis (type of arthritis affecting the spine)
Anxiety
Arthralgia (joint pain)

50-59:

Hypertension (high blood pressure)
Abdominal pain
Abscess (pus)
Acne (skin problems that cause pimples)
Alanine aminotransferase increased
Anaemia (lack of blood)
Arthralgia (joint pain)
Aspartate aminotransferase increased
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

60+:

Anxiety
Injury
Death
Fatigue (feeling of tiredness)
Constipation
Diarrhoea
Abdominal pain
Cataract (clouding of the lens inside the eye)
Dyspnoea (difficult or laboured respiration)
Flatulence (flatus expelled through the anus)

What are the existing conditions these people have? *

Hypersensitivity: 16 people, 21.33%
Diabetes: 13 people, 17.33%
Metastatic Neoplasm (spreadable cancer tumour): 11 people, 14.67%
Breast Cancer Metastatic: 11 people, 14.67%
Cardiac Disorder: 9 people, 12.00%
High Blood Cholesterol: 9 people, 12.00%
High Blood Pressure: 8 people, 10.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 10.67%
Infection: 6 people, 8.00%
Insomnia (sleeplessness): 5 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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