Apresoline and Bactrim ds drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Apresoline (hydralazine hydrochloride) and Bactrim ds (sulfamethoxazole; trimethoprim). Common drug interactions include bone fragmentation among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Apresoline and Bactrim ds. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Apresoline?

Apresoline has active ingredients of hydralazine hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 2,475 Apresoline users. Check the latest studies of Apresoline.

What is Bactrim ds?

Bactrim ds has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 17,027 Bactrim ds users. Check the latest studies of Bactrim ds.

On Jul, 12, 2026

42 people who take Apresoline and Bactrim ds together, and have interactions are studied.

Apresoline and Bactrim ds drug interactions.

What are the common drug interactions of Apresoline and Bactrim Ds, by gender? *:

female:

Bone fragmentation
Breast cancer recurrent
Candidiasis (candidiasis or thrush is a fungal infection)
Colitis (inflammation of colon)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Costochondritis (chest wall pain)
Depression
Device related infection
Disability
Electrolyte imbalance

male:

Pyrexia (fever)
Anaemia (lack of blood)
Blood urea increased
Bronchial haemorrhage (bleeding in bronchia)
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Constipation
Cough
Cystic fibrosis (disease of the secretary glands)
Dysphagia (a condition in which swallowing is difficult or painful)
Gastroenteritis norovirus (inflammation of stomach and intestine caused by norovirus infection)

What are the common drug interactions of Apresoline and Bactrim Ds, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Acidosis (build-up of carbon dioxide in the blood)
Acute respiratory distress syndrome
Anaemia (lack of blood)
Asthenia (weakness)
Bandaemia (excess of band cells (immature white blood cells) released by the bone marrow into the blood)
Blood creatinine increased
Blood urea increased
Bronchial haemorrhage (bleeding in bronchia)
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Constipation

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Blood bilirubin decreased
Blood creatinine increased
Blood glucose increased
Blood potassium increased
Blood sodium decreased
Blood urea increased
Carbon dioxide decreased
Chest pain

50-59:

Hypoxia (low oxygen in tissues)
Abscess rupture (pus release from the point of abscess)
Acquired porphyria (group of disorders that result in a build up of chemicals called porphyrins in the body)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anisocytosis (patient's red blood cells are of unequal size)
Anxiety
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Asthma

60+:

Candidiasis (candidiasis or thrush is a fungal infection)
Vomiting
Bone disorder
Bone fragmentation
Breast cancer recurrent
Colitis (inflammation of colon)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Costochondritis (chest wall pain)
Depression
Diarrhoea

What are the existing conditions these people have? *

Pain: 15 people, 35.71%
Asthma: 12 people, 28.57%
Wheezing (a high-pitched whistling sound made while you breath): 10 people, 23.81%
Sedation: 10 people, 23.81%
Cough: 10 people, 23.81%
Fungal Infection: 10 people, 23.81%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 9 people, 21.43%
Blood Glucose Decreased: 9 people, 21.43%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 9 people, 21.43%
Cystic Fibrosis (disease of the secretary glands): 9 people, 21.43%

* Approximation only. Some reports may have incomplete information.

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