Nicotine and Centrum drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nicotine (nicotine) and Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e). Common drug interactions include vision blurred among females and bile duct obstruction among males.

The phase IV clinical study analyzes what interactions people have when they take Nicotine and Centrum. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 20,443 Nicotine users. Check the latest studies of Nicotine.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

On Jul, 12, 2026

50 people who take Nicotine and Centrum together, and have interactions are studied.

What are the common drug interactions of Nicotine and Centrum, by gender? *:

female:

Vision blurred
Visual field defect
Weight increased
Drug ineffective
Fall
Lumbar radiculopathy (radicular pain in the low back and legs)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Synovial cyst (cyst of joint filled with synovial fluid)
Headache (pain in head)
Hot flush (sudden feelings of heat)

male:

Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Blood bilirubin increased
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cholecystitis (infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Post thrombotic syndrome (long-term effects that can occur after venous thrombosis)

What are the common drug interactions of Nicotine and Centrum, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)

30-39:

Application site erythema (redness of the skin at application site)
Application site pruritus (application site severe itching of the skin)
Dry skin
Nicotine dependence

40-49:

Drug ineffective
Back pain
Bacterial infection
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Dyspareunia (painful sexual intercourse)
Faecaloma (hard mass of fecal matter)
Gamma-glutamyltransferase increased
Incontinence (lack of moderation or self-control)
Loss of libido (loss of sexual urge)
Narcotic intoxication (a condition caused by use of narcotic agents)

50-59:

Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Blood bilirubin increased
Diarrhoea
Hyperglycaemia (high blood sugar)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Pain
Blood magnesium decreased
Blood sodium decreased
Muscle spasms (muscle contraction)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

60+:

Aphasia (damage to the parts of the brain that control language)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Femur fracture
Head injury
Overdose
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Visual field defect
Blood pressure increased
Bone density decreased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 30.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 22.00%
Wheezing (a high-pitched whistling sound made while you breath): 7 people, 14.00%
Pain: 7 people, 14.00%
Muscle Spasms (muscle contraction): 6 people, 12.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 12.00%
Erection Problems: 5 people, 10.00%
Pain In Extremity: 5 people, 10.00%
Oral Herpes (viral infection of mouth): 5 people, 10.00%
Mononeuropathy (a type of damage to nerves outside the brain and spinal cord): 5 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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