Apriso and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Apriso (mesalamine) and Methotrexate (methotrexate sodium). Common drug interactions include autoimmune disorder among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Apriso and Methotrexate. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Apriso?

Apriso has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 3,439 Apriso users. Check the latest studies of Apriso.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 14, 2026

73 people who take Apriso and Methotrexate together, and have interactions are studied.

Apriso and Methotrexate drug interactions.

What are the common drug interactions of Apriso and Methotrexate, by gender? *:

female:

Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Blood potassium decreased
Chest discomfort
Chills (felling of cold)
Colonic fistula (abnormal passage to other organ from colon)
Cough
Decreased appetite
Defaecation urgency (a sudden compelling urge to defecate)
Depressed mood
Disturbance in attention

male:

Diarrhoea
Pyrexia (fever)
Injection site haemorrhage (bleeding from injection site)
Injection site rash
Onychomadesis (a periodic idiopathic shedding of the nails)
Psoriasis (immune-mediated disease that affects the skin)
White blood cell count decreased
Fungal infection
Immunodeficiency
Lymphoproliferative disorder (a medical condition in which the immune system makes too many white blood cells)

What are the common drug interactions of Apriso and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Dizziness
Injection site erythema (redness at injection site)
Injection site swelling

10-19:

Ewing's sarcoma (malignant small, round, blue cell tumour)
Injection site pain
Inflammation
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Vomiting

20-29:

Abortion spontaneous (naturally occurring miscarriage)
Completed suicide (act of taking one's own life)
Death
Drug administration error
Joint dislocation (a joint position is changed from normal position)
Pregnancy

30-39:

Injection site erythema (redness at injection site)
Abdominal pain
Inflammatory marker increased
Injection site bruising
Injection site rash
Onychomadesis (a periodic idiopathic shedding of the nails)
Psoriasis (immune-mediated disease that affects the skin)
Rectal haemorrhage (bleeding from anus)
Vomiting
White blood cell count decreased

40-49:

Drug level decreased
Dysarthria (speech disorder)
Fibromyalgia (a long-term condition which causes pain all over the body)
Injection site pain
Onychoclasis (breaking of the nails)
Onychomadesis (a periodic idiopathic shedding of the nails)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Psychomotor hyperactivity (feelings of extreme restlessness)
Tremor (trembling or shaking movements in one or more parts of your body)
Abnormal faeces (abnormal stool)

50-59:

Pyrexia (fever)
Sinusitis (inflammation of sinus)
Diarrhoea
Influenza
Chills (felling of cold)
Dyspnoea (difficult or laboured respiration)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Pancreatitis (inflammation of pancreas)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

Drug ineffective
Arthralgia (joint pain)
Pain
Peripheral swelling
Post procedural stroke
Rash
Stress
Surgery
Unresponsive to stimuli
Anaemia (lack of blood)

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 39 people, 53.42%
Pain: 9 people, 12.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 12.33%
High Blood Pressure: 7 people, 9.59%
High Blood Cholesterol: 6 people, 8.22%
Depression: 6 people, 8.22%
Colitis (inflammation of colon): 6 people, 8.22%
Stress And Anxiety: 5 people, 6.85%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 6.85%

* Approximation only. Some reports may have incomplete information.

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