Arava and Restoril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arava (leflunomide) and Restoril (temazepam). Common drug interactions include anxiety among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Arava and Restoril. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

What is Restoril?

Restoril has active ingredients of temazepam. It is often used in insomnia. eHealthMe is studying from 13,522 Restoril users. Check the latest studies of Restoril.

On Jul, 11, 2026

72 people who take Arava and Restoril together, and have interactions are studied.

What are the common drug interactions of Arava and Restoril, by gender? *:

female:

Anxiety
Depression
Drug hypersensitivity
Pyrexia (fever)
Anaemia (lack of blood)
Muscular weakness (muscle weakness)
Nodule (a growth of abnormal tissue)
Asthenia (weakness)
Chills (felling of cold)
Intervertebral disc protrusion (spinal disc protrusion)

male:

Anxiety
Asthenia (weakness)
Hyperhidrosis (abnormally increased sweating)
Anger
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Headache (pain in head)
Hepatic echinococciasis (echinococcus multilocularis infection of liver)
Hyperthyroidism (over activity of the thyroid gland)
Memory impairment

What are the common drug interactions of Arava and Restoril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal discomfort
Behcet's syndrome (involves inflammation of the blood vessels)
Dizziness (excl vertigo)
Fibromyalgia (a long-term condition which causes pain all over the body)
Lethargy (tiredness)
Rash pruritic (redness with itching)
Total lung capacity decreased
Visual field defect
Vomiting

40-49:

Arthralgia (joint pain)
Influenza like illness
Pyrexia (fever)
Abdominal pain
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Back pain
Cardiac murmur (an heart sound in valve abnormality)
Chills (felling of cold)
Cholecystitis (infection of gallbladder)

50-59:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Gait disturbance
Headache (pain in head)
Hepatic echinococciasis (echinococcus multilocularis infection of liver)
Hyperthyroidism (over activity of the thyroid gland)
Monarthritis (inflammation (arthritis) of one joint at a time)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Blood pressure increased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

60+:

Pain
Gait disturbance
Onycholysis (detachment of the nail from the nail bed)
Nodule (a growth of abnormal tissue)
Exostosis (formation of new bone on the surface of a bone)
Head injury
Muscular weakness (muscle weakness)
Swelling
Haematuria (presence of blood in urine)
Muscle rupture (tear in muscle)

What are the existing conditions these people have? *

Pain: 17 people, 23.61%
High Blood Pressure: 15 people, 20.83%
High Blood Cholesterol: 13 people, 18.06%
Thyroid Diseases: 9 people, 12.50%
Fibromyalgia (a long-term condition which causes pain all over the body): 7 people, 9.72%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 8.33%
Diabetes: 5 people, 6.94%
Bone Disorder: 5 people, 6.94%
Stress And Anxiety: 4 people, 5.56%
Sleep Disorder: 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Arava and Restoril?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously