Artane and Ultram drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Artane (trihexyphenidyl hydrochloride) and Ultram (tramadol hydrochloride). Common drug interactions include asthma among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Artane and Ultram. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Artane?

Artane has active ingredients of trihexyphenidyl hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 3,619 Artane users. Check the latest studies of Artane.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

On Jul, 15, 2026

22 people who take Artane and Ultram together, and have interactions are studied.

What are the common drug interactions of Artane and Ultram, by gender? *:

female:

Asthma
Bone loss
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Breast cancer
Breast mass
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bundle branch block (disruption in the normal flow of electrical pulses that drive the heart beat)
Cardiac enzymes increased
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)

male:

Nausea (feeling of having an urge to vomit)
Diarrhoea
Depression
Drug abuser
Drug dependence
Dysarthria (speech disorder)
Epistaxis (bleed from the nose)
Excoriation (to tear or wear off the skin of)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hallucination, auditory (perceiving sounds without auditory stimulus)

What are the common drug interactions of Artane and Ultram, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug abuser
Drug dependence
Drug ineffective
Dysarthria (speech disorder)
Epistaxis (bleed from the nose)
Excoriation (to tear or wear off the skin of)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hypoaesthesia (reduced sense of touch or sensation)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

40-49:

Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Drug toxicity
Nervousness
Restlessness (not able to rest)
Weight decreased
Abdominal pain
Colitis (inflammation of colon)
Colonic polyp (extra part of colon tissue grow in intestine)
Diarrhoea

50-59:

Activities of daily living impaired
Anger
Anxiety
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Breast cancer
Breast mass
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bundle branch block (disruption in the normal flow of electrical pulses that drive the heart beat)
Cardiac enzymes increased

60+:

Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Bone loss
Osteosclerosis (an elevation in bone density)
Pain in jaw
Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone)
Procedural pain
Stomach discomfort (pain in abdomen)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Vomiting
Exposed bone in jaw

What are the existing conditions these people have? *

Stress And Anxiety: 2 people, 9.09%
Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 2 people, 9.09%
Osteoporosis (bones weak and more likely to break): 2 people, 9.09%
Muscle Rigidity (muscle stiffness): 2 people, 9.09%
Hypersensitivity: 2 people, 9.09%
High Blood Cholesterol: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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