Astepro and Skelaxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Astepro (azelastine hydrochloride) and Skelaxin (metaxalone). Common drug interactions include abdominal pain among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Astepro and Skelaxin. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Astepro?

Astepro has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 3,336 Astepro users. Check the latest studies of Astepro.

What is Skelaxin?

Skelaxin has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 9,706 Skelaxin users. Check the latest studies of Skelaxin.

On Jul, 07, 2026

36 people who take Astepro and Skelaxin together, and have interactions are studied.

What are the common drug interactions of Astepro and Skelaxin, by gender? *:

female:

Abdominal pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Compression fracture (fracture due to pressure caused by injury)
Deafness
Dizziness
Drug ineffective
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Inflammation
Nausea (feeling of having an urge to vomit)

male:

Drug ineffective
Hepatic enzyme increased
Hepatic neoplasm (liver tumour)
Hepatic steatosis (fatty liver disease)
Oedema (fluid collection in tissue)

What are the common drug interactions of Astepro and Skelaxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abasia (inability to walk)
Arthropathy
Compression fracture (fracture due to pressure caused by injury)
Deafness
Drug ineffective
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Oral disorder (mouth disease)
Retinal disorder (disease of retina)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Cheilitis (infection of lips)

20-29:

n/a

30-39:

Anxiety
Palpitations (feelings or sensations that your heart is pounding or racing)
Precancerous skin lesion
Surgery

40-49:

Injury
Oedema (fluid collection in tissue)
Pain
Pulmonary embolism (blockage of the main artery of the lung)
Abdominal abscess (collection of pus in abdomen)
Abdominal pain
Anxiety
Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cholecystitis chronic (long lasting infection of gallbladder)

50-59:

Body tinea (ringworm of the body)
Cerumen impaction
Cystitis (inflammation of the wall of the bladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Emotional distress
Fall
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cough
Dry eye (lack of adequate tears)
Headache (pain in head)

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 17 people, 47.22%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 17 people, 47.22%
Depression: 5 people, 13.89%
Asthma: 4 people, 11.11%
High Blood Pressure: 3 people, 8.33%
Multiple Allergies (allergy to multiple agents): 3 people, 8.33%
Immunodeficiency Common Variable: 3 people, 8.33%
Fungal Infection: 2 people, 5.56%
Bacterial Infection: 2 people, 5.56%
Cough: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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