Avinza and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avinza (morphine sulfate) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include depression among females and infusion related reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Avinza and Benadryl. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Avinza?

Avinza has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 1,728 Avinza users. Check the latest studies of Avinza.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,955 Benadryl users. Check the latest studies of Benadryl.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

23 people who take Avinza and Benadryl together, and have interactions are studied.

What are the common drug interactions of Avinza and Benadryl, by gender? *:

female:

Depression
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Abdominal adhesions (inflammation of abdomen)
Aortic valve incompetence
Asthma
Cardiomyopathy (weakening of the heart muscle)
Costochondritis (chest wall pain)
Dyspareunia (painful sexual intercourse)
Dyspnoea (difficult or laboured respiration)
Ejection fraction decreased (systolic heart failure)

male:

Infusion related reaction
Completed suicide (act of taking one's own life)
Drug abuse
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Chronic kidney disease
Death
Malignant neoplasm progression (cancer tumour came back)
Renal failure (kidney dysfunction)

What are the common drug interactions of Avinza and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control

40-49:

Death
Fatigue (feeling of tiredness)
Headache (pain in head)
Limb injury
Malignant neoplasm progression (cancer tumour came back)
Oesophageal irritation
Pain in extremity
Peripheral nerve injury
Renal injury (kidney injury)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)

50-59:

Asthma
Cardiomyopathy (weakening of the heart muscle)
Chest pain
Costochondritis (chest wall pain)
Depression
Dyspareunia (painful sexual intercourse)
Ejection fraction decreased (systolic heart failure)
Fibromyalgia (a long-term condition which causes pain all over the body)
Headache (pain in head)
Hypertriglyceridaemia (excess of triglycerides in the blood)

60+:

Cellulitis (infection under the skin)
Drug hypersensitivity
Erythema of eyelid (redness of the eyelid)
Extrasystoles
Eyelid oedema (eyelids are swollen and contain excessive fluid)
Lymphoedema (localized fluid retention and tissue swelling)
Peripheral swelling

What are the existing conditions these people have? *

Depression: 8 people, 34.78%
Stress And Anxiety: 7 people, 30.43%
Asthma: 6 people, 26.09%
Hypersensitivity: 6 people, 26.09%
Sleep Disorder: 5 people, 21.74%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 17.39%
Cardiac Disorder: 4 people, 17.39%
Seasonal Allergy (allergic condition due to certain season): 3 people, 13.04%
Nausea (feeling of having an urge to vomit): 3 people, 13.04%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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