Azelastine and Zosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Azelastine (azelastine hydrochloride) and Zosyn (piperacillin sodium; tazobactam sodium). Common drug interactions include hyperglycaemia among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Azelastine and Zosyn. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Azelastine?

Azelastine has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 17,400 Azelastine users. Check the latest studies of Azelastine.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

On Jul, 26, 2026

20 people who take Azelastine and Zosyn together, and have interactions are studied.

What are the common drug interactions of Azelastine and Zosyn, by gender? *:

female:

Hyperglycaemia (high blood sugar)
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium)
Hypertension (high blood pressure)
Hypoacusis (loss of hearing)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypokalaemia (low potassium)
Hypotension (abnormally low blood pressure)
Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
Hypoxia (low oxygen in tissues)
Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)

male:

Dyspnoea (difficult or laboured respiration)
Sepsis (a severe blood infection that can lead to organ failure and death)
Cellulitis (infection under the skin)
Cystic fibrosis (disease of the secretary glands)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depressed mood
Groin abscess (pus in groin)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Increased viscosity of bronchial secretion
Malaise (a feeling of general discomfort or uneasiness)

What are the common drug interactions of Azelastine and Zosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood sodium decreased
Bronchial secretion retention
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Burkholderia cepacia complex infection (complex infection by group of bacteria burkholderia cepacia -resistant to common antibiotics)
Cystic fibrosis (disease of the secretary glands)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depressed mood
Dyspnoea (difficult or laboured respiration)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Increased viscosity of bronchial secretion

40-49:

Sepsis (a severe blood infection that can lead to organ failure and death)
Abscess (pus)
Abscess limb (limb infection)
Anal abscess
Cellulitis (infection under the skin)
Dyspnoea (difficult or laboured respiration)
Groin abscess (pus in groin)
Perirectal abscess
Rectal abscess (pus in rectum)
Renal failure (kidney dysfunction)

50-59:

Pyrexia (fever)
Respiratory disorder (respiratory disease)
Respiratory distress (difficulty in breathing)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Scleritis (inflammation of sclera)
Secretion discharge
Sepsis (a severe blood infection that can lead to organ failure and death)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Somnolence (a state of near-sleep, a strong desire for sleep)
Sputum culture positive

60+:

Abscess (pus)
Adenocarcinoma pancreas (cancer of pancreas)
Dementia (madness)
Depression
Drug intolerance (drug sensitivity)
Fall
Fatigue (feeling of tiredness)
Hospitalisation
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 6 people, 30.00%
Weight Decreased: 5 people, 25.00%
Type 2 Diabetes: 5 people, 25.00%
Hypotension (abnormally low blood pressure): 5 people, 25.00%
Pain: 3 people, 15.00%
Hiv Infection: 2 people, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.00%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 10.00%
Constipation: 2 people, 10.00%
Cough: 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Azelastine and Zosyn?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously