Tofranil and Restoril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tofranil (imipramine hydrochloride) and Restoril (temazepam). Common drug interactions include diabetic ketoacidosis among females and overdose among males.

The phase IV clinical study analyzes what interactions people have when they take Tofranil and Restoril. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Tofranil?

Tofranil has active ingredients of imipramine hydrochloride. It is often used in depression. eHealthMe is studying from 2,012 Tofranil users. Check the latest studies of Tofranil.

What is Restoril?

Restoril has active ingredients of temazepam. It is often used in insomnia. eHealthMe is studying from 13,522 Restoril users. Check the latest studies of Restoril.

On Jul, 26, 2026

12 people who take Tofranil and Restoril together, and have interactions are studied.

Tofranil and Restoril drug interactions.

What are the common drug interactions of Tofranil and Restoril, by gender? *:

female:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Urinary tract infection
Suicide attempt
Abdominal pain
Accident
Drug ineffective
Hallucination (an experience involving the perception of something not present)
Intestinal resection
Menometrorrhagia (a condition in which prolonged or excessive uterine bleeding occurs irregularly and more frequently than normal)
Ovarian cyst (fluid filled sac of the ovary)

male:

Overdose
Aggression
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Completed suicide (act of taking one's own life)
Hallucination (an experience involving the perception of something not present)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Chest pain
Confusion
Death
Hospitalisation

What are the common drug interactions of Tofranil and Restoril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Menometrorrhagia (a condition in which prolonged or excessive uterine bleeding occurs irregularly and more frequently than normal)
Ovarian cyst (fluid filled sac of the ovary)

30-39:

Suicide attempt
Suicidal ideation

40-49:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Urinary tract infection
Chest pain
Death
Hospitalisation
Overdose
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

50-59:

Hallucination (an experience involving the perception of something not present)
Aggression
Completed suicide (act of taking one's own life)
Overdose
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Accident
Drug ineffective
Restlessness (not able to rest)

60+:

Confusion
Intestinal resection

What are the existing conditions these people have? *

Stress And Anxiety: 2 people, 16.67%
Sleep Disorder: 2 people, 16.67%
Nausea (feeling of having an urge to vomit): 2 people, 16.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 16.67%
Flatulence (flatus expelled through the anus): 2 people, 16.67%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 1 person, 8.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 8.33%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 8.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Tofranil and Restoril?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously