Bactrim and Accolate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Accolate (zafirlukast). Common drug interactions include hepatitis among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Accolate. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Accolate?

Accolate has active ingredients of zafirlukast. It is often used in asthma. eHealthMe is studying from 4,220 Accolate users. Check the latest studies of Accolate.

On Jul, 08, 2026

54 people who take Bactrim and Accolate together, and have interactions are studied.

What are the common drug interactions of Bactrim and Accolate, by gender? *:

female:

Hepatitis (inflammation of the liver)
Lacunar infarction (a type of stroke)
Weakness
Autoimmune hepatitis
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Drug ineffective
Hepatomegaly (abnormal enlargement of the liver)
Pain
Urine discolouration
Vomiting

male:

Arthralgia (joint pain)
Colitis ulcerative (inflammation of colon with ulcer)
Fatigue (feeling of tiredness)
Fistula (an abnormal connection or passageway between two)
Insomnia (sleeplessness)
Mood swings (an extreme or rapid change in mood)
Muscle twitching
Night sweats (sweating in night)
Proctalgia (pain in the rectum)
Suicidal ideation

What are the common drug interactions of Bactrim and Accolate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arthralgia (joint pain)
Colitis ulcerative (inflammation of colon with ulcer)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Gastroenteritis bacterial (inflammation of stomach and intestine by bacterial infection)
Inflammatory bowel disease
Rectal haemorrhage (bleeding from anus)
Abdominal pain upper
Anxiety
Depression
Fatigue (feeling of tiredness)

20-29:

n/a

30-39:

Anxiety
Apnoea (suspension of external breathing)
Bacterial infection
Biliary cirrhosis primary (primary biliary cirrhosis (pbc) is a long-term liver disease that damages the small bile ducts in the liver. the build-up of bile damages the liver)
Blood bilirubin increased
Blood immunoglobulin m increased
Blood magnesium decreased
Blood pressure decreased
Cerebral haemorrhage (bleeding within the brain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

40-49:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Coagulopathy (blood's ability to clot is impaired)
Injury
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Transverse sinus thrombosis (a blood clot in transverse sinus)

50-59:

Back pain
Diffuse large b-cell lymphoma (cancer of b cells, a type of white blood cell)
Malaise (a feeling of general discomfort or uneasiness)
B-cell lymphoma (blood cancer affecting b cells)
Blindness
Bone pain
Churg strauss syndrome (infection of small arteries and vein)
Fracture
Loose tooth
Myalgia (muscle pain)

60+:

Drug ineffective
Dyspnoea (difficult or laboured respiration)
Aggression
Asthenia (weakness)
Blood immunoglobulin g decreased
Bradycardia (abnormally slow heart action)
Confusional state
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Disease progression

What are the existing conditions these people have? *

Pain: 15 people, 27.78%
Sinobronchitis (long lasting paranasal sinusitis with repeated bronchitis): 11 people, 20.37%
Infection: 11 people, 20.37%
Diarrhea: 11 people, 20.37%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 11 people, 20.37%
Acne (skin problems that cause pimples): 11 people, 20.37%
High Blood Pressure: 5 people, 9.26%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 4 people, 7.41%
Sinusitis (inflammation of sinus): 3 people, 5.56%
Multiple Allergies (allergy to multiple agents): 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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