Enulose and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enulose (lactulose) and Methotrexate (methotrexate sodium). Common drug interactions include pain in extremity among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Enulose and Methotrexate. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Enulose?

Enulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 711 Enulose users. Check the latest studies of Enulose.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 08, 2026

14 people who take Enulose and Methotrexate together, and have interactions are studied.

Enulose and Methotrexate drug interactions.

What are the common drug interactions of Enulose and Methotrexate, by gender? *:

female:

Pain in extremity
Arthralgia (joint pain)
Back disorder
Nerve compression
Pain
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Amblyopia (lazy eye)
Cataract (clouding of the lens inside the eye)
Depression
Eye disorder

male:

Diarrhoea
Epistaxis (bleed from the nose)
Febrile neutropenia (fever with reduced white blood cells)
Gingival bleeding (bleeding gums)
Haematochezia (passage of stools containing blood)
Rhinorrhoea (watery mucus discharge from the nose)
Upper respiratory tract infection
Haemoglobin decreased
Platelet count decreased
Viral upper respiratory tract infection

What are the common drug interactions of Enulose and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Diarrhoea
Epistaxis (bleed from the nose)
Febrile neutropenia (fever with reduced white blood cells)
Gingival bleeding (bleeding gums)
Haematochezia (passage of stools containing blood)
Rhinorrhoea (watery mucus discharge from the nose)
Upper respiratory tract infection
Haemoglobin decreased
Platelet count decreased
Viral upper respiratory tract infection

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Depression
Emotional disorder
Dry mouth
Dysuria (painful or difficult urination)
Eosinophil percentage increased
Fatigue (feeling of tiredness)
Injection site pain
Lymphocyte percentage increased
Malaise (a feeling of general discomfort or uneasiness)
Monocyte percentage increased

What are the existing conditions these people have? *

Pain: 6 people, 42.86%
High Blood Cholesterol: 6 people, 42.86%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 35.71%
Swelling: 4 people, 28.57%
Productive Cough: 4 people, 28.57%
Anaemia (lack of blood): 4 people, 28.57%
Laxative Supportive Care: 4 people, 28.57%
Indigestion: 4 people, 28.57%
Hypersensitivity: 4 people, 28.57%
Folate Deficiency (lack of folic acid): 4 people, 28.57%

* Approximation only. Some reports may have incomplete information.

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