Bactrim and Norflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Norflex (orphenadrine citrate). Common drug interactions include oedema lower limb among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Norflex. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,951 Norflex users. Check the latest studies of Norflex.

On Jul, 12, 2026

19 people who take Bactrim and Norflex together, and have interactions are studied.

What are the common drug interactions of Bactrim and Norflex, by gender? *:

female:

Oedema lower limb (fluid collection in tissue of lower leg)
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)
Renal failure (kidney dysfunction)
Social problem
Swelling
Upper respiratory tract infection
Vomiting
Weight increased
Abasia (inability to walk)

male:

Abdominal pain
Agitation (state of anxiety or nervous excitement)
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Delirium (wild excitement)
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

What are the common drug interactions of Bactrim and Norflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Anaemia (lack of blood)
Anxiety
Asthenia (weakness)
Atrioventricular dissociation (av block)
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiomegaly (increased size of heart than normal)
Cellulitis (infection under the skin)

30-39:

n/a

40-49:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Cardiomyopathy (weakening of the heart muscle)
Chest pain
Chest tightness
Mitral valve incompetence (inefficient heart valve)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)

50-59:

Upper limb fracture
Uterine cancer
Ventricular fibrillation (abnormally irregular heart rhythm)
Vomiting
Abdominal pain
Agitation (state of anxiety or nervous excitement)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Blood glucose increased

60+:

Drug hypersensitivity
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Asthma
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Bipolar disorder (mood disorder)
Blood cholesterol increased
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Burns third degree
Cardiac failure congestive
Cellulitis (infection under the skin)

What are the existing conditions these people have? *

Heart Rate Irregular: 3 people, 15.79%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.53%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 10.53%
High Blood Pressure: 2 people, 10.53%
Pain: 2 people, 10.53%
High Blood Cholesterol: 2 people, 10.53%
Depression: 2 people, 10.53%
Sleep Disorder: 1 person, 5.26%
Hypersensitivity: 1 person, 5.26%
Hepatitis C: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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