Belbuca and Creon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Belbuca (buprenorphine hydrochloride) and Creon (pancrelipase (amylase;lipase;protease)). Common drug interactions include hypersensitivity among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Belbuca and Creon. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Belbuca?

Belbuca has active ingredients of buprenorphine hydrochloride. eHealthMe is studying from 3,022 Belbuca users. Check the latest studies of Belbuca.

What is Creon?

Creon has active ingredients of pancrelipase (amylase;lipase;protease). It is often used in pancreatitis. eHealthMe is studying from 29,489 Creon users. Check the latest studies of Creon.

On Jul, 16, 2026

12 people who take Belbuca and Creon together, and have interactions are studied.

What are the common drug interactions of Belbuca and Creon, by gender? *:

female:

Hypersensitivity
Anaphylactic reaction (serious allergic reaction)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
General physical health deterioration (weak health status)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Stress
Abdominal pain
Acidosis (build-up of carbon dioxide in the blood)
Asthenia (weakness)
Blood glucose decreased

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Staphylococcal infection (an infection with staphylococcus bacteria)
Pelvic infection
Post procedural haemorrhage (post procedural bleeding)
Surgical failure
Wound
Abscess limb (limb infection)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Drug ineffective
Gastroenteritis staphylococcal (inflammation of stomach and intestine caused by staphylococcal infection)

What are the common drug interactions of Belbuca and Creon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Sepsis (a severe blood infection that can lead to organ failure and death)
Staphylococcal infection (an infection with staphylococcus bacteria)
Abscess limb (limb infection)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Drug ineffective
Gastroenteritis staphylococcal (inflammation of stomach and intestine caused by staphylococcal infection)
Haemoglobin decreased
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Large intestinal haemorrhage (bleeding in large intestine)

50-59:

Parkinson's disease
Pyrexia (fever)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Weight decreased
Asthenia (weakness)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Oropharyngeal pain

60+:

Anaphylactic reaction (serious allergic reaction)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Hypersensitivity
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Stress

What are the existing conditions these people have? *

Stress And Anxiety: 3 people, 25.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 25.00%
High Blood Cholesterol: 3 people, 25.00%
Hypersensitivity: 2 people, 16.67%
Back Disorder: 2 people, 16.67%
Back Pain: 2 people, 16.67%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 16.67%
Depression: 2 people, 16.67%
Hereditary Angioedema (recurrent episodes of severe swelling): 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Belbuca and Creon?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously