Benadryl and Acthar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Acthar (corticotropin). Common drug interactions include delirium among females and flushing among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Acthar. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,956 Benadryl users. Check the latest studies of Benadryl.

What is Acthar?

Acthar has active ingredients of corticotropin. eHealthMe is studying from 4,948 Acthar users. Check the latest studies of Acthar.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

48 people who take Benadryl and Acthar together, and have interactions are studied.

What are the common drug interactions of Benadryl and Acthar, by gender? *:

female:

Delirium (wild excitement)
Discomfort
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug ineffective
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Gait disturbance
Muscular weakness (muscle weakness)
Asthenia (weakness)
Hypoaesthesia (reduced sense of touch or sensation)

male:

Flushing (the warm, red condition of human skin)
Nausea (feeling of having an urge to vomit)
Hypertension (high blood pressure)
Hypoacusis (loss of hearing)
Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)
Surgery
Tremor (trembling or shaking movements in one or more parts of your body)
Pneumonia
Adverse reaction
Alanine aminotransferase increased

What are the common drug interactions of Benadryl and Acthar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abnormal behaviour
Aneurysm (enlargement of an artery caused by a weakening of the artery wall)
Anger
Irritability
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Vomiting

10-19:

n/a

20-29:

Abdominal discomfort
Abdominal pain upper
Dyspepsia (indigestion)

30-39:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Asthenia (weakness)
Balance disorder
Cardiac flutter (abnormal heart rhythm)
Chest discomfort
Dizziness
Fall
Fatigue (feeling of tiredness)
Feeling drunk

40-49:

Abdominal discomfort
Pneumonia
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Contusion (a type of hematoma of tissue in which capillaries)
Dizziness
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
Haemorrhage (bleeding)

50-59:

Fatigue (feeling of tiredness)
Iron deficiency anaemia
Muscle disorder (muscle disease)
Oedema peripheral (superficial swelling)
Muscular weakness (muscle weakness)
Hypotension (abnormally low blood pressure)
Asthenia (weakness)
Dizziness
Muscle spasms (muscle contraction)
Hypoaesthesia (reduced sense of touch or sensation)

60+:

Abdominal pain upper
Asthenia (weakness)
Back pain
Dry mouth
Energy increased
Fatigue (feeling of tiredness)
Herpes zoster
Oedema peripheral (superficial swelling)
Rash
Rectal haemorrhage (bleeding from anus)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 17 people, 35.42%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 7 people, 14.58%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 10.42%
Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 10.42%
Gait Disturbance: 4 people, 8.33%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 4 people, 8.33%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 6.25%
Back Pain: 3 people, 6.25%
Asthma: 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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