Benadryl and Azilect drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Azilect (rasagiline mesylate). Common drug interactions include dyskinesia among females and hallucination among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Azilect. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,955 Benadryl users. Check the latest studies of Benadryl.

What is Azilect?

Azilect has active ingredients of rasagiline mesylate. It is often used in parkinson's disease. eHealthMe is studying from 8,622 Azilect users. Check the latest studies of Azilect.

On Aug, 07, 2026

23 people who take Benadryl and Azilect together, and have interactions are studied.

What are the common drug interactions of Benadryl and Azilect, by gender? *:

female:

Dyskinesia (abnormality or impairment of voluntary movement)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Feeding disorder (when children refuse to eat certain food groups)
Hallucination (an experience involving the perception of something not present)
Head injury
Heart rate increased
Heart rate irregular
Hospitalisation

male:

Hallucination (an experience involving the perception of something not present)
Dehydration (dryness resulting from the removal of water)
Anxiety
Constipation
Dyskinesia (abnormality or impairment of voluntary movement)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Fall
Fatigue (feeling of tiredness)
Psychotic disorder

What are the common drug interactions of Benadryl and Azilect, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Abdominal pain upper
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Dizziness
Somnolence (a state of near-sleep, a strong desire for sleep)
Vision blurred

60+:

Hallucination (an experience involving the perception of something not present)
Dehydration (dryness resulting from the removal of water)
Heart rate irregular
Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral swelling
Presyncope
Rash
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Anaemia (lack of blood)

What are the existing conditions these people have? *

Nasopharyngitis (inflammation of the nasopharynx): 4 people, 17.39%
Hyperkalemia (damage to or disease of the kidney): 4 people, 17.39%
Hypersensitivity: 3 people, 13.04%
Hallucinations (sensations that appear real but are created by your mind): 3 people, 13.04%
Dyskinesia (abnormality or impairment of voluntary movement): 3 people, 13.04%
Delusion (a false belief or opinion): 3 people, 13.04%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 2 people, 8.70%
High Blood Pressure: 2 people, 8.70%
High Blood Cholesterol: 2 people, 8.70%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and Azilect?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously