Benadryl and Cefaclor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Cefaclor (cefaclor). Common drug interactions include diabetic neuropathy among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Cefaclor. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Cefaclor?

Cefaclor has active ingredients of cefaclor. eHealthMe is studying from 2,512 Cefaclor users. Check the latest studies of Cefaclor.

On Jul, 16, 2026

42 people who take Benadryl and Cefaclor together, and have interactions are studied.

Benadryl and Cefaclor drug interactions.

What are the common drug interactions of Benadryl and Cefaclor, by gender? *:

female:

Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Fall
Hyperlipidaemia (presence of excess lipids in the blood)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pyrexia (fever)
Abdominal pain upper
Atrophic vulvovaginitis (inflammation of the vulva)
Carotid artery disease
Carotid artery occlusion (artery blockage)

male:

Abdominal pain
Anxiety
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic obstructive airways disease
Constipation
Cor pulmonale (enlargement of the right ventricle of the heart)
Diarrhoea
Drug hypersensitivity
Feeling jittery
Foot ulcer

What are the common drug interactions of Benadryl and Cefaclor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Aggression
Agitation (state of anxiety or nervous excitement)
Anger
Arthralgia (joint pain)
Chest pain
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Irritability
Lipid metabolism disorder (genetic disorders are caused by errors in fatty acid metabolism)

20-29:

n/a

30-39:

Abdominal discomfort
Abdominal pain
Angioedema (rapid swelling of the dermis)
Blood pressure increased
Diarrhoea
Dry eye (lack of adequate tears)
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphemia (stammering or stuttering)
Dysphonia (speech disorder attributable to a disorder of phonation)
Eye inflammation

40-49:

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Cough
Deafness
Depression
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dizziness
Dry eye (lack of adequate tears)
Dysphagia (a condition in which swallowing is difficult or painful)
Essential hypertension (primary hypertension)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Depression
Drug hypersensitivity
Cystitis (inflammation of the wall of the bladder)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Kidney infection
Nephrogenic anaemia (anaemia due to kidney disease)
Renal impairment (severely reduced kidney function)

60+:

Abdominal pain
Anxiety
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic kidney disease
Chronic obstructive airways disease
Constipation
Cor pulmonale (enlargement of the right ventricle of the heart)
Diarrhoea
Drug hypersensitivity
Feeling jittery

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 28.57%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 9 people, 21.43%
Pain: 9 people, 21.43%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 19.05%
High Blood Pressure: 7 people, 16.67%
Muscle Spasms (muscle contraction): 7 people, 16.67%
Stress And Anxiety: 7 people, 16.67%
Hypersensitivity: 6 people, 14.29%
Nausea (feeling of having an urge to vomit): 6 people, 14.29%
Infection: 6 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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