Benadryl and Ciloxan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Ciloxan (ciprofloxacin hydrochloride). Common drug interactions include chronic kidney disease among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Ciloxan. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,955 Benadryl users. Check the latest studies of Benadryl.

What is Ciloxan?

Ciloxan has active ingredients of ciprofloxacin hydrochloride. eHealthMe is studying from 613 Ciloxan users. Check the latest studies of Ciloxan.

On Aug, 06, 2026

20 people who take Benadryl and Ciloxan together, and have interactions are studied.

What are the common drug interactions of Benadryl and Ciloxan, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac failure congestive
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypotension (abnormally low blood pressure)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Sepsis (a severe blood infection that can lead to organ failure and death)

male:

Abdominal pain
Anxiety
Cellulitis (infection under the skin)
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic obstructive airways disease
Constipation
Cor pulmonale (enlargement of the right ventricle of the heart)
Diarrhoea
Drug hypersensitivity

What are the common drug interactions of Benadryl and Ciloxan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Asthma
Bronchial hyperreactivity
Respiratory tract infection

60+:

Cardiac failure congestive
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Breast cancer male
Breast lump (localized swelling that feels different from the surrounding breast tissue)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cellulitis (infection under the skin)
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic kidney disease

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 50.00%
Pain: 5 people, 25.00%
High Blood Cholesterol: 4 people, 20.00%
Diabetes: 4 people, 20.00%
Headache (pain in head): 4 people, 20.00%
Infection: 4 people, 20.00%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 4 people, 20.00%
Blood Pressure Abnormal: 3 people, 15.00%
Hypersensitivity: 2 people, 10.00%
Weakness: 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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