Benadryl and Exalgo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Exalgo (hydromorphone hydrochloride). Common drug interactions include essential hypertension among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Exalgo. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,955 Benadryl users. Check the latest studies of Benadryl.

What is Exalgo?

Exalgo has active ingredients of hydromorphone hydrochloride. It is often used in chronic pain. eHealthMe is studying from 9,847 Exalgo users. Check the latest studies of Exalgo.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

25 people who take Benadryl and Exalgo together, and have interactions are studied.

What are the common drug interactions of Benadryl and Exalgo, by gender? *:

female:

Essential hypertension (primary hypertension)
Extradural abscess (pus may gather between a patient's skull and his dura)
Fluid imbalance (imbalance of fluid in body in intake and fluid lost)
Gait disturbance
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Gastroenteritis (inflammation of stomach and intestine)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrointestinal infection (infection of stomach and intestine)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Glomerulonephritis chronic (long lasting group of conditions that affect parts of the kidneys called glomeruli)

male:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Hospitalisation
Hot flush (sudden feelings of heat)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypokalaemia (low potassium)
Loss of consciousness
Mouth ulceration (mouth ulcers)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)

What are the common drug interactions of Benadryl and Exalgo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Asthenia (weakness)
Back pain
Chest discomfort
Chest pain
Contusion (a type of hematoma of tissue in which capillaries)
Dizziness

40-49:

Back pain
Dizziness
Fatigue (feeling of tiredness)
Headache (pain in head)
Abdominal pain upper
Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Anxiety
Asthenia (weakness)
Blood bilirubin increased
Blood lactate dehydrogenase increased

50-59:

Lip swelling
Loss of consciousness
Malaise (a feeling of general discomfort or uneasiness)
Mouth ulceration (mouth ulcers)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)
Odynophagia (painful swallowing, in the mouth (oropharynx) or oesophagus)
Oesophagitis (inflammation of oesophagus)
Pain in extremity
Pyrexia (fever)

60+:

Nausea (feeling of having an urge to vomit)
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Confusional state
Constipation
Fatigue (feeling of tiredness)
Parosmia (distortion of the sense of smell, as in smelling odours that are not present)
Sluggishness (lacking alertness)
Drug ineffective
Vomiting

What are the existing conditions these people have? *

Pain: 6 people, 24.00%
Back Pain: 5 people, 20.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 16.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 16.00%
High Blood Pressure: 3 people, 12.00%
Nausea And Vomiting: 3 people, 12.00%
Nausea (feeling of having an urge to vomit): 3 people, 12.00%
Itching: 3 people, 12.00%
Sleep Disorder: 2 people, 8.00%
Breakthrough Pain: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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