Benadryl and Levocarnitine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Levocarnitine (levocarnitine). Common drug interactions include dermatitis contact among females and seizure among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Levocarnitine. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,955 Benadryl users. Check the latest studies of Benadryl.

What is Levocarnitine?

Levocarnitine has active ingredients of levocarnitine. It is often used in mitochondrial myopathy. eHealthMe is studying from 3,332 Levocarnitine users. Check the latest studies of Levocarnitine.

On Aug, 01, 2026

50 people who take Benadryl and Levocarnitine together, and have interactions are studied.

Benadryl and Levocarnitine drug interactions.

What are the common drug interactions of Benadryl and Levocarnitine, by gender? *:

female:

Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Fatigue (feeling of tiredness)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Arrhythmia (irregular heartbeat)
Cystic fibrosis (disease of the secretary glands)
Headache (pain in head)
Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (subset of children and adolescents who have obsessive compulsive disorder (ocd) and/or tic disorders, and in whom symptoms worsen following strep. infections such as ""strep throat"" and scarlet fever)
Chronic kidney disease
Abdominal distension

male:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Hyperkalaemia (damage to or disease of the kidney)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Respiratory distress (difficulty in breathing)
Retching (strong involuntary effort to vomit)
Swelling face
Tongue biting
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal distension
Abdominal tenderness

What are the common drug interactions of Benadryl and Levocarnitine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Hyperhidrosis (abnormally increased sweating)
Influenza
Infusion related reaction
Nasopharyngitis (inflammation of the nasopharynx)
Pneumonia
Rash
Sinusitis (inflammation of sinus)
Skin irritation
Urinary tract infection

10-19:

Hyperhidrosis (abnormally increased sweating)
Infection
Infusion related reaction
Rash
Sinusitis (inflammation of sinus)
Skin irritation
Weight decreased
Weight increased
Incision site abscess
Urinary tract infection

20-29:

Agitation (state of anxiety or nervous excitement)
Blood sodium increased
Headache (pain in head)
Hypersensitivity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Psychomotor hyperactivity (feelings of extreme restlessness)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Throat irritation

30-39:

Ammonia increased
Asthenia (weakness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Abdominal pain

40-49:

n/a

50-59:

Chronic kidney disease
Cardiac flutter (abnormal heart rhythm)
Decreased appetite
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Drug hypersensitivity
Inflammation
Muscle twitching
Nervousness
Rash

60+:

n/a

What are the existing conditions these people have? *

Metabolic Disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues): 7 people, 14.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 10.00%
Constipation: 4 people, 8.00%
Chronic Fatigue Syndrome (disorder that causes extreme fatigue): 4 people, 8.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 6.00%
Pain: 3 people, 6.00%
Nausea (feeling of having an urge to vomit): 3 people, 6.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 6.00%
Multiple Myeloma (cancer of the plasma cells): 3 people, 6.00%
Insomnia (sleeplessness): 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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