Benadryl and Magnesium aspartate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Magnesium aspartate (magnesium). Common drug interactions include neutrophil count decreased among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Magnesium aspartate. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Magnesium aspartate?

Magnesium aspartate has active ingredients of magnesium. eHealthMe is studying from 1,871 Magnesium aspartate users. Check the latest studies of Magnesium aspartate.

On Jul, 18, 2026

24 people who take Benadryl and Magnesium aspartate together, and have interactions are studied.

Benadryl and Magnesium aspartate drug interactions.

What are the common drug interactions of Benadryl and Magnesium Aspartate, by gender? *:

female:

Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Constipation
Skin infection
Abdominal pain
Back pain
Blood creatine phosphokinase increased
Cataract (clouding of the lens inside the eye)
Chest discomfort
Coronary arterial stent insertion
Fluid retention (an abnormal accumulation of fluid in the blood)

male:

Pneumonia
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nausea (feeling of having an urge to vomit)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Unresponsive to stimuli
Back injury
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Dizziness

What are the common drug interactions of Benadryl and Magnesium Aspartate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Blood pressure decreased
Feeling cold
Headache (pain in head)
Lower respiratory tract infection
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Migraine (headache)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nausea (feeling of having an urge to vomit)

50-59:

Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Lip injury
Pneumonia
Skin infection
Blood creatine phosphokinase increased
Muscle spasms (muscle contraction)

60+:

Abdominal pain
Back injury
Renal failure (kidney dysfunction)
Swelling
Weight increased
Back pain
Dizziness
Fall
Fluid retention (an abnormal accumulation of fluid in the blood)
Hypertension (high blood pressure)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 6 people, 25.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 16.67%
Hyperkalemia (damage to or disease of the kidney): 4 people, 16.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 16.67%
Ovarian Cancer (cancer of ovary): 3 people, 12.50%
Adverse Event: 3 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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