Benadryl and Microzide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Microzide (hydrochlorothiazide). Common drug interactions include lichen planus among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Microzide. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Microzide?

Microzide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 994 Microzide users. Check the latest studies of Microzide.

On Jul, 27, 2026

32 people who take Benadryl and Microzide together, and have interactions are studied.

Benadryl and Microzide drug interactions.

What are the common drug interactions of Benadryl and Microzide, by gender? *:

female:

Lichen planus (an inflammatory skin condition, characterized by an itchy, non-infectious rash)
Limb injury
Loss of consciousness
Malignant neoplasm progression (cancer tumour came back)
Mitral valve incompetence (inefficient heart valve)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)
Neuralgia (pain in one or more nerves)
Night sweats (sweating in night)
Oesophageal ulcer (ulcer of oesophagus)

male:

Anxiety
Depression
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state
Disturbance in attention
Drug ineffective
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fall

What are the common drug interactions of Benadryl and Microzide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Migraine (headache)
Myelopathy (any neurologic deficit related to the spinal cord)
Palpitations (feelings or sensations that your heart is pounding or racing)
Personality disorder
Social problem
Spinal osteoarthritis (joint cartilage loss in spine)
Spondylitis (an inflammation of the vertebra with spinal cord involvement)
Suicidal ideation
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

50-59:

Abasia (inability to walk)
Asthenia (weakness)
Blood pressure diastolic decreased
Blood pressure systolic increased
Gastric ulcer (stomach ulcer)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Limb injury
Neuralgia (pain in one or more nerves)
Oesophageal ulcer (ulcer of oesophagus)
Osteopenia (a condition where bone mineral density is lower than normal)

60+:

Urinary tract infection
Diarrhoea
Bone pain
Bradycardia (abnormally slow heart action)
Cellulitis (infection under the skin)
Cerebral atrophy (decrement in size of brain)
Cerebral venous thrombosis (clot in brains venous blood system)
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coagulopathy (blood's ability to clot is impaired)

What are the existing conditions these people have? *

Pain: 11 people, 34.38%
Nausea (feeling of having an urge to vomit): 8 people, 25.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 21.88%
Itching: 7 people, 21.88%
Nausea And Vomiting: 6 people, 18.75%
Stress And Anxiety: 5 people, 15.62%
Headache (pain in head): 5 people, 15.62%
Muscle Spasms (muscle contraction): 5 people, 15.62%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 12.50%
Hypersensitivity: 4 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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