Benadryl and Zerit drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Zerit (stavudine). Common drug interactions include renal failure among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Zerit. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,955 Benadryl users. Check the latest studies of Benadryl.

What is Zerit?

Zerit has active ingredients of stavudine. eHealthMe is studying from 9,912 Zerit users. Check the latest studies of Zerit.

On Aug, 10, 2026

42 people who take Benadryl and Zerit together, and have interactions are studied.

What are the common drug interactions of Benadryl and Zerit, by gender? *:

female:

Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Death
Emotional distress
Lactic acidosis (low ph in body tissues)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

male:

Chronic kidney disease
Emotional distress
Arthralgia (joint pain)
Bone density decreased
Hypoaesthesia (reduced sense of touch or sensation)
Renal tubular necrosis (death of kidney tubules)
Abdominal pain
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the common drug interactions of Benadryl and Zerit, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abnormal behaviour
Aggression
Bipolar disorder (mood disorder)
Difficulty in walking
Drooling (drop saliva uncontrollably from the mouth)
Increased appetite
Mental retardation severity unspecified (problems with learning and developing severity unspecified)
Paralysis
Staring (a prolonged gaze or fixed look)
Swelling face

20-29:

Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)

30-39:

Arthralgia (joint pain)
Depression
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Diarrhoea
Muscle cramps (painful sensations caused by muscle contraction)
Red eye
Vasculitis (inflammation of a blood vessel or blood vessels)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Back pain
Blood culture positive

40-49:

Hypoaesthesia (reduced sense of touch or sensation)
Rash
Blepharitis (chronic inflammation of the eyelid)
Malignant neoplasm of conjunctiva (cancer tumour of conjunctiva)

50-59:

Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Cough
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Drug toxicity
Epistaxis (bleed from the nose)
Hypotension (abnormally low blood pressure)

60+:

Lactic acidosis (low ph in body tissues)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Renal impairment (severely reduced kidney function)

What are the existing conditions these people have? *

Hiv Infection: 12 people, 28.57%
Hepatitis B: 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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