Benzaclin and Flonase drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benzaclin (benzoyl peroxide; clindamycin phosphate) and Flonase (fluticasone propionate). Common drug interactions include chest pain among females and hospitalisation among males.

The phase IV clinical study analyzes what interactions people have when they take Benzaclin and Flonase. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Benzaclin?

Benzaclin has active ingredients of benzoyl peroxide; clindamycin phosphate. It is often used in acne. eHealthMe is studying from 477 Benzaclin users. Check the latest studies of Benzaclin.

What is Flonase?

Flonase has active ingredients of fluticasone propionate. It is often used in allergies. eHealthMe is studying from 75,441 Flonase users. Check the latest studies of Flonase.



On Jul, 13, 2026

15 people who take Benzaclin and Flonase together, and have interactions are studied.

Benzaclin and Flonase drug interactions.

What are the common drug interactions of Benzaclin and Flonase, by gender? *:

female:

  1. Chest pain
  2. Dyspnoea (difficult or laboured respiration)
  3. Pulmonary embolism (blockage of the main artery of the lung)
  4. Abdominal pain
  5. Breast enlargement
  6. Depression
  7. Diarrhoea
  8. Drug hypersensitivity
  9. Drug intolerance (drug sensitivity)
  10. Foot fracture

male:

  1. Hospitalisation
  2. Infection
  3. Malignant neoplasm progression (cancer tumour came back)
  4. Pain
  5. Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
  6. Pulmonary function test decreased
  7. Rhinovirus infection
  8. Urinary tract infection
  9. Anxiety
  10. Chronic sinusitis (long lasting inflammation of the paranasal sinuses)

What are the common drug interactions of Benzaclin and Flonase, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Hospitalisation
  2. Infection
  3. Rhinovirus infection
  4. Urinary tract infection
  5. Therapeutic response unexpected

20-29:

  1. Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
  2. Infective exacerbation of bronchiectasis (severe infective lung disease)
  3. Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
  4. Pain
  5. Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
  6. Pulmonary function test decreased
  7. Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)

30-39:

  1. Chest pain
  2. Dyspnoea (difficult or laboured respiration)
  3. Pulmonary embolism (blockage of the main artery of the lung)
  4. Breast enlargement
  5. Drug intolerance (drug sensitivity)
  6. Weight increased

40-49:

  1. Abdominal pain
  2. Muscle rupture (tear in muscle)
  3. Muscle spasms (muscle contraction)
  4. Muscular weakness (muscle weakness)
  5. Nocturia (the need to get up in the night to urinate)
  6. Oral herpes (viral infection of mouth)
  7. Peptic ulcer
  8. Peripheral coldness
  9. Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
  10. Swelling

50-59:

  1. Malignant neoplasm progression (cancer tumour came back)

60+:

n/a

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 33.33%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 20.00%
  3. Hypersensitivity: 3 people, 20.00%
  4. Wheezing (a high-pitched whistling sound made while you breath): 2 people, 13.33%
  5. Itching: 2 people, 13.33%
  6. Cough: 2 people, 13.33%
  7. Dyspnea (difficult or laboured breathing): 2 people, 13.33%
  8. Fever: 2 people, 13.33%
  9. Infection: 2 people, 13.33%
  10. Premenstrual Syndrome: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Benzaclin and Flonase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Benzaclin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Flonase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Benzaclin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Flonase and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on benzoyl peroxide; clindamycin phosphate and fluticasone propionate (the active ingredients of Benzaclin and Flonase, respectively), and Benzaclin and Flonase (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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