Benzonatate and Roxicet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benzonatate (benzonatate) and Roxicet (acetaminophen; oxycodone hydrochloride). Common drug interactions include nausea among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Benzonatate and Roxicet. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

What is Roxicet?

Roxicet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 2,254 Roxicet users. Check the latest studies of Roxicet.

On Jul, 10, 2026

45 people who take Benzonatate and Roxicet together, and have interactions are studied.

Benzonatate and Roxicet drug interactions.

What are the common drug interactions of Benzonatate and Roxicet, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Osteoporosis (bones weak and more likely to break)
Palpitations (feelings or sensations that your heart is pounding or racing)
Panic reaction
Pneumonia
Rash
Road traffic accident
Suicidal ideation
Tinnitus (a ringing in the ears)
Visual disturbance

male:

Emotional distress
Anxiety
Gynaecomastia (enlargement of the gland tissue of the male breast)
Herpes zoster
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hot flush (sudden feelings of heat)
Injury
Leukopenia (less number of white blood cells in blood)
Metastatic neoplasm (spreadable cancer tumour)
Nephrolithiasis (calculi in the kidneys)

What are the common drug interactions of Benzonatate and Roxicet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chronic kidney disease
Renal failure (kidney dysfunction)

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Drug addiction
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Suicide attempt

40-49:

Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)
Panic reaction
Pneumonia
Rash
Road traffic accident
Suicidal ideation
Tinnitus (a ringing in the ears)
Visual disturbance
Vomiting

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Dyspepsia (indigestion)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Asthenia (weakness)
Chest discomfort
Chest pain
Confusional state

60+:

Anxiety
Emotional distress
Herpes zoster
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hot flush (sudden feelings of heat)
Hypertension (high blood pressure)
Injury
Leukopenia (less number of white blood cells in blood)
Metastatic neoplasm (spreadable cancer tumour)
Nephrolithiasis (calculi in the kidneys)

What are the existing conditions these people have? *

High Blood Pressure: 22 people, 48.89%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 21 people, 46.67%
High Blood Cholesterol: 17 people, 37.78%
Infection: 16 people, 35.56%
Stress And Anxiety: 13 people, 28.89%
Fluid Retention (an abnormal accumulation of fluid in the blood): 13 people, 28.89%
Swelling: 10 people, 22.22%
Osteoporosis (bones weak and more likely to break): 10 people, 22.22%
Inflammation: 10 people, 22.22%
Metastases To Bone (cancer spreads to bone): 9 people, 20.00%

* Approximation only. Some reports may have incomplete information.

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