Benzonatate and Sudafed 12 hour drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benzonatate (benzonatate) and Sudafed 12 hour (pseudoephedrine hydrochloride). Common drug interactions include dyspnoea among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Benzonatate and Sudafed 12 hour. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

What is Sudafed 12 hour?

Sudafed 12 hour has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 4,687 Sudafed 12 hour users. Check the latest studies of Sudafed 12 hour.

On Jul, 17, 2026

15 people who take Benzonatate and Sudafed 12 hour together, and have interactions are studied.

Benzonatate and Sudafed 12 hour drug interactions.

What are the common drug interactions of Benzonatate and Sudafed 12 Hour, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Blood pressure decreased
Chronic kidney disease
Pneumonia
Suicidal ideation
Urinary tract infection
Abdominal pain
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cardiac disorder

male:

Asthenia (weakness)
Brain natriuretic peptide increased
Pneumonia
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Respiratory failure (inadequate gas exchange by the respiratory system)
Rib fracture
Ventricular extrasystoles (premature cardiac contraction)
Small cell lung cancer (small cell cancer tumour of lung)
Dyspnoea (difficult or laboured respiration)
Immune system disorder

What are the common drug interactions of Benzonatate and Sudafed 12 Hour, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Cardiac disorder
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Injury
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Pain

30-39:

Cholecystitis chronic (long lasting infection of gallbladder)
Gallbladder disorder

40-49:

Anxiety
Joint swelling
Stress
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Uveitis (inflammation of the uvea)
Weight increased

50-59:

Urinary tract infection

60+:

Asthenia (weakness)
Brain natriuretic peptide increased
Pneumonia
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Respiratory failure (inadequate gas exchange by the respiratory system)
Rib fracture
Ventricular extrasystoles (premature cardiac contraction)
Small cell lung cancer (small cell cancer tumour of lung)
Dyspnoea (difficult or laboured respiration)
Immune system disorder

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 46.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 33.33%
Drowsiness: 3 people, 20.00%
Lung Cancer - Small Cell (lung cancer): 3 people, 20.00%
Lambert-Eaton Syndrome (this means your immune system mistakenly targets healthy cells and tissues in the body): 3 people, 20.00%
Asthma: 2 people, 13.33%
Constipation: 1 person, 6.67%
Birth Control: 1 person, 6.67%
Candidiasis (candidiasis or thrush is a fungal infection): 1 person, 6.67%
Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Benzonatate and Sudafed 12 hour?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously