Blenoxane and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Blenoxane (bleomycin sulfate) and Methotrexate (methotrexate sodium). Common drug interactions include amenorrhoea among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Blenoxane and Methotrexate. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Blenoxane?

Blenoxane has active ingredients of bleomycin sulfate. eHealthMe is studying from 155 Blenoxane users. Check the latest studies of Blenoxane.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 19, 2026

12 people who take Blenoxane and Methotrexate together, and have interactions are studied.

Blenoxane and Methotrexate drug interactions.

What are the common drug interactions of Blenoxane and Methotrexate, by gender? *:

female:

Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Chronic myeloid leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood)
Hepatitis (inflammation of the liver)
Ovarian disorder (disease of ovary)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pulmonary oedema (fluid accumulation in the lungs)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Anaemia (lack of blood)
Metastases to lung (cancer spreads to lung)
Multi-organ failure (multisystem organ failure)

male:

Dyspnoea (difficult or laboured respiration)
Hypoxia (low oxygen in tissues)
Procedural site reaction
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Thromboembolism (obstruction of artery by blood clot)

What are the common drug interactions of Blenoxane and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Anaemia (lack of blood)
Metastases to lung (cancer spreads to lung)
Multi-organ failure (multisystem organ failure)
Acute monocytic leukaemia (in remission)
Hepatitis (inflammation of the liver)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pulmonary oedema (fluid accumulation in the lungs)

20-29:

Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Ovarian disorder (disease of ovary)

30-39:

Skin discolouration (change of skin colour)
Skin lesion
Chronic myeloid leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood)
Livedo reticularis (a lace-like purplish discoloration of the skin)
Pain
Rash erythematous (redness of the skin)
Rash macular (small, flat red spots)

40-49:

Procedural site reaction
Thromboembolism (obstruction of artery by blood clot)

50-59:

n/a

60+:

Dyspnoea (difficult or laboured respiration)
Hypoxia (low oxygen in tissues)
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)

* Approximation only. Some reports may have incomplete information.

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