Bosentan and Acetaminophen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bosentan (bosentan) and Acetaminophen (acetaminophen). Common drug interactions include hypothermia among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Bosentan and Acetaminophen. It is created by eHealthMe based on reports of 89 people who take the same drugs from the FDA, and is updated regularly.

What is Bosentan?

Bosentan has active ingredients of bosentan. eHealthMe is studying from 10,925 Bosentan users. Check the latest studies of Bosentan.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

On Jul, 09, 2026

89 people who take Bosentan and Acetaminophen together, and have interactions are studied.

Bosentan and Acetaminophen drug interactions.

What are the common drug interactions of Bosentan and Acetaminophen, by gender? *:

female:

Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Oxygen saturation decreased
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Sinusitis (inflammation of sinus)
Tricuspid valve incompetence (inefficient heart valve)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Bacteraemia (presence of bacteria in the blood)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Oedema (fluid collection in tissue)
Panic disorder

male:

Dyspnoea (difficult or laboured respiration)
Haemoglobin decreased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dizziness
Ear infection
Erythema (redness of the skin)
Hepatic enzyme increased
Irritability
Palpitations (feelings or sensations that your heart is pounding or racing)
Pneumonia

What are the common drug interactions of Bosentan and Acetaminophen, by age (0-1 to 60+)? *:

0-1:

Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Oxygen saturation decreased
Pleural effusion (water on the lungs)
Weight decreased
Body temperature increased
Brain natriuretic peptide increased
Diarrhoea
Failure to thrive (inadequate weight gain and physical growth in children)
Hepatomegaly (abnormal enlargement of the liver)
Hypokalaemia (low potassium)

2-9:

Oxygen saturation decreased
Pulmonary hypertension (increase in blood pressure in the lung artery)
Respiratory failure (inadequate gas exchange by the respiratory system)
Respiratory rate increased (excess breathing rate/min)
Cardiac arrest
Hyperkalaemia (damage to or disease of the kidney)
Respiratory distress (difficulty in breathing)
Respiratory tract infection
Tracheitis (an inflammation of the trachea)

10-19:

Bradycardia (abnormally slow heart action)
Cough
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Dyspnoea (difficult or laboured respiration)
Hypoaesthesia (reduced sense of touch or sensation)
Infusion site reaction
Injection site abscess
Injection site erythema (redness at injection site)
Injection site induration

20-29:

n/a

30-39:

Normal newborn
Pregnancy
Premature delivery

40-49:

Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Bacteraemia (presence of bacteria in the blood)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Diarrhoea
Oedema (fluid collection in tissue)
Panic disorder
Right ventricular failure (right half of the heart fails to work)
Hypotension (abnormally low blood pressure)
Renal failure (kidney dysfunction)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

50-59:

Injection site injury
Insulin-like growth factor increased
Lactose intolerance (inability to digest lactose)
Myalgia (muscle pain)
Neuropathy peripheral (surface nerve damage)
Oesophagitis (inflammation of oesophagus)
Presyncope
Renal haematoma (blood collection in kidney)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Right ventricular failure (right half of the heart fails to work)

60+:

Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Hypotension (abnormally low blood pressure)
Sinusitis (inflammation of sinus)
Tricuspid valve incompetence (inefficient heart valve)
Hypoxia (low oxygen in tissues)
Cardiomegaly (increased size of heart than normal)
Mouth injury
Pleural effusion (water on the lungs)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Unresponsive to stimuli

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 59 people, 66.29%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 29 people, 32.58%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 9 people, 10.11%
Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 6 people, 6.74%
Nausea (feeling of having an urge to vomit): 6 people, 6.74%
Low Birth Weight Baby: 5 people, 5.62%

* Approximation only. Some reports may have incomplete information.

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