Brintellix and Effexor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Brintellix (vortioxetine hydrobromide) and Effexor (venlafaxine hydrochloride). Common drug interactions include cough among females and suicidal ideation among males.

The phase IV clinical study analyzes what interactions people have when they take Brintellix and Effexor. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Brintellix?

Brintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 6,748 Brintellix users. Check the latest studies of Brintellix.

What is Effexor?

Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,493 Effexor users. Check the latest studies of Effexor.

On Jul, 10, 2026

84 people who take Brintellix and Effexor together, and have interactions are studied.

Brintellix and Effexor drug interactions.

What are the common drug interactions of Brintellix and Effexor, by gender? *:

female:

Cough
Dehydration (dryness resulting from the removal of water)
Depressive symptom
Dizziness
Elevated mood
Erythema (redness of the skin)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Feeding disorder (when children refuse to eat certain food groups)
Flushing (the warm, red condition of human skin)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

male:

Suicidal ideation
Suicide attempt
Depressed mood
Homeless
Hyperhidrosis (abnormally increased sweating)
Impulse-control disorder
Insomnia (sleeplessness)
Intentional self-injury
Logorrhoea (excessive, uncontrollable, or incoherent talkativeness)
Loss of employment

What are the common drug interactions of Brintellix and Effexor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Suicide attempt

20-29:

Pain
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

30-39:

Overdose
Suicide attempt

40-49:

Tobacco abuse
Vomiting
Headache (pain in head)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Colonoscopy
Diarrhoea
Pneumonia
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Weight increased
Abnormal dreams

50-59:

Irritability
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)
Back pain
Drug ineffective
Nephrogenic anaemia (anaemia due to kidney disease)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Suicidal ideation

60+:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Inappropriate antidiuretic hormone secretion
Suicidal ideation
Dehydration (dryness resulting from the removal of water)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
Nausea (feeling of having an urge to vomit)
Salivary hypersecretion (excess saliva secretion)
Vomiting

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 28 people, 33.33%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 11 people, 13.10%
Stress And Anxiety: 7 people, 8.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 8.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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