Buprenorphine and Provigil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Buprenorphine (buprenorphine) and Provigil (modafinil). Common drug interactions include sepsis among females and amnesia among males.

The phase IV clinical study analyzes what interactions people have when they take Buprenorphine and Provigil. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Buprenorphine?

Buprenorphine has active ingredients of buprenorphine. It is often used in opioid intoxication. eHealthMe is studying from 9,053 Buprenorphine users. Check the latest studies of Buprenorphine.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

On Jul, 25, 2026

15 people who take Buprenorphine and Provigil together, and have interactions are studied.

Buprenorphine and Provigil drug interactions.

What are the common drug interactions of Buprenorphine and Provigil, by gender? *:

female:

Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting
Application site erythema (redness of the skin at application site)
Application site irritation
Application site pruritus (application site severe itching of the skin)
Application site rash
Application site swelling
Application site vesicles (small bubble within a cell at application site)
Skin exfoliation (removal of the oldest dead skin cells)
Urticaria (rash of round, red welts on the skin that itch intensely)

male:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Parkinson's disease
Delirium (wild excitement)
Rib fracture
Upper limb fracture
Victim of crime
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

What are the common drug interactions of Buprenorphine and Provigil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Headache (pain in head)
Hypertension (high blood pressure)
Palpitations (feelings or sensations that your heart is pounding or racing)

40-49:

Application site erythema (redness of the skin at application site)
Application site irritation
Anxiety
Apnoea (suspension of external breathing)
Blindness transient (sudden loss of vision)
Drug dependence
Enuresis (repeated inability to control urination)
Gallbladder operation
Helicobacter test positive
Keratomileusis

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 73.33%
Drowsiness: 3 people, 20.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 6.67%
Back Pain: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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