Bydureon and Avalide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bydureon (exenatide synthetic) and Avalide (hydrochlorothiazide; irbesartan). Common drug interactions include injection site pain among females and injection site haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Bydureon and Avalide. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Bydureon?

Bydureon has active ingredients of exenatide synthetic. It is often used in type 2 diabetes. eHealthMe is studying from 24,309 Bydureon users. Check the latest studies of Bydureon.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

14 people who take Bydureon and Avalide together, and have interactions are studied.

What are the common drug interactions of Bydureon and Avalide, by gender? *:

female:

Injection site pain
Injection site mass
Increased appetite
Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)
Nausea (feeling of having an urge to vomit)
Weight decreased
Feeding disorder (when children refuse to eat certain food groups)
Injection site extravasation (flow of (blood or lymph) from injection site)
Blood glucose decreased
Blood glucose increased

male:

Injection site haemorrhage (bleeding from injection site)
Blood glucose increased
Injection site pruritus (severe itching at injection site)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Blood pressure diastolic increased
Early satiety (feeling full before completing a normal sized meal)
Erythema (redness of the skin)
Nausea (feeling of having an urge to vomit)
Vomiting

What are the common drug interactions of Bydureon and Avalide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Injection site mass
Injection site pain
Increased appetite
Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)
Nausea (feeling of having an urge to vomit)
Weight decreased
Feeding disorder (when children refuse to eat certain food groups)
Blood glucose decreased
Anxiety
Asthenia (weakness)

60+:

Injection site pain
Injection site extravasation (flow of (blood or lymph) from injection site)
Vomiting
Weight decreased
Abdominal pain upper
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Chronic kidney disease
Dyspepsia (indigestion)
Injection site bruising
Injection site erythema (redness at injection site)

What are the existing conditions these people have? *

Diabetes: 7 people, 50.00%
High Blood Cholesterol: 4 people, 28.57%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 14.29%
Blood Pressure Abnormal: 2 people, 14.29%
Gastric Disorder (disease of stomach): 1 person, 7.14%
Asthma: 1 person, 7.14%
Back Pain: 1 person, 7.14%
Blood Glucose Increased: 1 person, 7.14%
Bronchitis Chronic (inflammation of the mucous membrane in the bronchial tubes- chronic): 1 person, 7.14%
Cardiac Disorder: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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