Penicillin and Risperidone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Penicillin (penicillin g potassium) and Risperidone (risperidone). Common drug interactions include chronic kidney disease among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Penicillin and Risperidone. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Penicillin?

Penicillin has active ingredients of penicillin g potassium. It is often used in strep throat. eHealthMe is studying from 8,567 Penicillin users. Check the latest studies of Penicillin.

What is Risperidone?

Risperidone has active ingredients of risperidone. It is often used in bipolar disorder. eHealthMe is studying from 72,175 Risperidone users. Check the latest studies of Risperidone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Sep, 03, 2026

44 people who take Penicillin and Risperidone together, and have interactions are studied.

Penicillin and Risperidone drug interactions.

What are the common drug interactions of Penicillin and Risperidone, by gender? *:

female:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
  4. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  5. Anxiety
  6. Bone density decreased
  7. Diarrhoea
  8. Drug hypersensitivity
  9. Emotional distress
  10. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

male:

  1. Emotional distress
  2. Pain
  3. Rash
  4. Renal impairment (severely reduced kidney function)
  5. Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
  6. Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
  7. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  8. Back pain
  9. Exercise tolerance decreased
  10. General physical health deterioration (weak health status)

What are the common drug interactions of Penicillin and Risperidone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  2. Injection site swelling
  3. Liver transplant rejection (failure of liver transplant)

20-29:

  1. Rash
  2. Renal failure (kidney dysfunction)
  3. Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
  4. Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
  5. Lung injury
  6. Tachypnoea (a condition of rapid breathing over 20 per minute)
  7. Contrast media reaction (reaction associated with the use of intravenous contrast material during radiology)
  8. Disease progression
  9. Myocardiac abscess (a pus containing infection of myocardium)
  10. Post procedural complication

30-39:

n/a

40-49:

  1. Emotional distress
  2. Pain
  3. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  4. Anxiety
  5. Osteopenia (a condition where bone mineral density is lower than normal)
  6. Bone density decreased
  7. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  8. Back pain
  9. General physical health deterioration (weak health status)
  10. Multiple fractures

50-59:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Bone density decreased
  4. Emotional distress
  5. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  6. Mobility decreased (ability to move is reduced)
  7. Nephrogenic anaemia (anaemia due to kidney disease)
  8. Osteoporosis (bones weak and more likely to break)
  9. Pain
  10. Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

60+:

  1. Chronic kidney disease
  2. Diarrhoea
  3. Hepatic enzyme increased
  4. Onychalgia (nail biting)
  5. Pruritus (severe itching of the skin)
  6. Pyelonephritis (inflammation of kidney caused by bacteria)
  7. Syncope (loss of consciousness with an inability to maintain postural tone)
  8. Vomiting
  9. White blood cell count increased
  10. Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 36.36%
  2. Depression: 15 people, 34.09%
  3. Pain: 15 people, 34.09%
  4. Hiv Infection: 13 people, 29.55%
  5. High Blood Cholesterol: 13 people, 29.55%
  6. Infection: 12 people, 27.27%
  7. Inflammation: 11 people, 25.00%
  8. High Blood Pressure: 11 people, 25.00%
  9. Hypersensitivity: 11 people, 25.00%
  10. Stress And Anxiety: 11 people, 25.00%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Penicillin and Risperidone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Penicillin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Risperidone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Penicillin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Risperidone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on penicillin g potassium and risperidone (the active ingredients of Penicillin and Risperidone, respectively), and Penicillin and Risperidone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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