Butrans and Acetaminophen and codeine phosphate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Butrans (buprenorphine) and Acetaminophen and codeine phosphate (acetaminophen; codeine phosphate). Common drug interactions include blood creatinine increased among females and adverse drug reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Butrans and Acetaminophen and codeine phosphate. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Butrans?

Butrans has active ingredients of buprenorphine. It is often used in pain. eHealthMe is studying from 64,148 Butrans users. Check the latest studies of Butrans.

What is Acetaminophen and codeine phosphate?

Acetaminophen and codeine phosphate has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 3,220 Acetaminophen and codeine phosphate users. Check the latest studies of Acetaminophen and codeine phosphate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

25 people who take Butrans and Acetaminophen and codeine phosphate together, and have interactions are studied.

Butrans and Acetaminophen and codeine phosphate drug interactions.

What are the common drug interactions of Butrans and Acetaminophen And Codeine Phosphate, by gender? *:

female:

Blood creatinine increased
Blood urea increased
Glomerular filtration rate decreased
Hyperkalaemia (damage to or disease of the kidney)
Infection
Malaise (a feeling of general discomfort or uneasiness)
Renal failure acute (rapid kidney dysfunction)
Abdominal discomfort
Abortion spontaneous (naturally occurring miscarriage)
Anaphylactic reaction (serious allergic reaction)

male:

Adverse drug reaction
Completed suicide (act of taking one's own life)

What are the common drug interactions of Butrans and Acetaminophen And Codeine Phosphate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Maternal exposure during pregnancy (use of substance during pregnancy)
Intra-uterine death
Drug exposure during pregnancy
Drug ineffective
Foetal death (death of foetus)
Stillbirth (a birth of dead foetus)
Abortion spontaneous (naturally occurring miscarriage)
Foetal hypokinesia (decreased bodily movement of foetus)

40-49:

n/a

50-59:

Abdominal discomfort
Anaphylactic reaction (serious allergic reaction)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Interstitial lung disease
Pleural effusion (water on the lungs)
Pyrexia (fever)
Respiratory failure (inadequate gas exchange by the respiratory system)

60+:

Blood creatinine increased
Blood urea increased
Completed suicide (act of taking one's own life)
Blood pressure diastolic decreased
Confusional state
Dysarthria (speech disorder)
Somnolence (a state of near-sleep, a strong desire for sleep)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Glomerular filtration rate decreased

What are the existing conditions these people have? *

Symphysiolysis (pain around the symphysis pubis join): 15 people, 60.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 8.00%
Maternal Exposure During Pregnancy (use of substance during pregnancy): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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