Bydureon and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bydureon (exenatide synthetic) and Methotrexate (methotrexate sodium). Common drug interactions include fungal infection among females and blood glucose increased among males.

The phase IV clinical study analyzes what interactions people have when they take Bydureon and Methotrexate. It is created by eHealthMe based on reports of 95 people who take the same drugs from the FDA, and is updated regularly.

What is Bydureon?

Bydureon has active ingredients of exenatide synthetic. It is often used in type 2 diabetes. eHealthMe is studying from 24,309 Bydureon users. Check the latest studies of Bydureon.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 29, 2026

95 people who take Bydureon and Methotrexate together, and have interactions are studied.

Bydureon and Methotrexate drug interactions.

What are the common drug interactions of Bydureon and Methotrexate, by gender? *:

female:

Fungal infection
Abdominal distension
Activities of daily living impaired
Acute myocardial infarction (acute heart attack)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Anosmia (partial or complete loss of the sense of smell)
Antinuclear antibody increased
Arthropathy
Asthma

male:

Blood glucose increased
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Memory impairment
Muscle spasms (muscle contraction)
Night blindness (inability to see in night as day)
Blood glucose fluctuation
Blood pressure increased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chronic kidney disease
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Bydureon and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Injection site pain
Arthralgia (joint pain)
Blood potassium decreased
Blood pressure increased
Blood sodium decreased
Bone cyst
Drug effect decreased
Fibromyalgia (a long-term condition which causes pain all over the body)
Finger deformity (a deformed position of the finger)
Hepatic lesion

40-49:

Cystitis (inflammation of the wall of the bladder)
Nausea (feeling of having an urge to vomit)
Sepsis (a severe blood infection that can lead to organ failure and death)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chronic kidney disease
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Drug eruption (adverse drug reaction of the skin)
Ear infection

50-59:

Night blindness (inability to see in night as day)
Acute myocardial infarction (acute heart attack)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Antinuclear antibody increased
Asthenia (weakness)
Asthma
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Blood glucose fluctuation
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)

60+:

Blood glucose increased
Pain
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Asthenia (weakness)
Diarrhoea
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Fungal skin infection
Hair disorder
Injection site mass

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 16 people, 16.84%
High Blood Cholesterol: 14 people, 14.74%
Psoriasis (immune-mediated disease that affects the skin): 12 people, 12.63%
Pain: 12 people, 12.63%
Diabetes: 12 people, 12.63%
High Blood Pressure: 10 people, 10.53%
Fibromyalgia (a long-term condition which causes pain all over the body): 9 people, 9.47%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 8.42%
Depression: 7 people, 7.37%
Blood Pressure Abnormal: 7 people, 7.37%

* Approximation only. Some reports may have incomplete information.

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