Bystolic and Sular drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bystolic (nebivolol hydrochloride) and Sular (nisoldipine). Common drug interactions include chronic kidney disease among females and pruritus among males.

The phase IV clinical study analyzes what interactions people have when they take Bystolic and Sular. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Bystolic?

Bystolic has active ingredients of nebivolol hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 20,662 Bystolic users. Check the latest studies of Bystolic.

What is Sular?

Sular has active ingredients of nisoldipine. It is often used in high blood pressure. eHealthMe is studying from 1,757 Sular users. Check the latest studies of Sular.



On Jul, 18, 2026

18 people who take Bystolic and Sular together, and have interactions are studied.

Bystolic and Sular drug interactions.

What are the common drug interactions of Bystolic and Sular, by gender? *:

female:

  1. Chronic kidney disease
  2. Drug ineffective
  3. Headache (pain in head)
  4. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  5. Application site dermatitis
  6. Application site pruritus (application site severe itching of the skin)
  7. Back pain
  8. Brain injury
  9. Chest pain
  10. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

male:

  1. Pruritus (severe itching of the skin)
  2. Abdominal discomfort
  3. Alopecia (absence of hair from areas of the body)
  4. Arthralgia (joint pain)
  5. Balance disorder
  6. Decreased appetite
  7. Dizziness
  8. Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
  9. Hypotension (abnormally low blood pressure)
  10. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

What are the common drug interactions of Bystolic and Sular, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Renal transplant

50-59:

n/a

60+:

  1. Pruritus (severe itching of the skin)
  2. Abdominal discomfort
  3. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  4. Malaise (a feeling of general discomfort or uneasiness)
  5. Alopecia (absence of hair from areas of the body)
  6. Application site dermatitis
  7. Application site pruritus (application site severe itching of the skin)
  8. Arthralgia (joint pain)
  9. Back pain
  10. Balance disorder

What are the existing conditions these people have? *

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 16.67%
  2. High Blood Cholesterol: 2 people, 11.11%
  3. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 11.11%
  4. Thyroid Diseases: 1 person, 5.56%
  5. Anaemia (lack of blood): 1 person, 5.56%
  6. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.56%
  7. Blood Phosphorus Increased: 1 person, 5.56%
  8. Blood Pressure Abnormal: 1 person, 5.56%
  9. Gout (uric acid crystals building up in the body): 1 person, 5.56%
  10. High Density Lipoprotein Decreased: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Bystolic and Sular?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Bystolic and Sular:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Bystolic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Sular:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Bystolic and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Sular and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on nebivolol hydrochloride and nisoldipine (the active ingredients of Bystolic and Sular, respectively), and Bystolic and Sular (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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