Caffeine and Abilify drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Caffeine (caffeine) and Abilify (aripiprazole). Common drug interactions include craniocerebral injury among females and obsessive-compulsive disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Caffeine and Abilify. It is created by eHealthMe based on reports of 94 people who take the same drugs from the FDA, and is updated regularly.

What is Caffeine?

Caffeine has active ingredients of caffeine. It is often used in fatigue. eHealthMe is studying from 6,667 Caffeine users. Check the latest studies of Caffeine.

What is Abilify?

Abilify has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 101,456 Abilify users. Check the latest studies of Abilify.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

94 people who take Caffeine and Abilify together, and have interactions are studied.

What are the common drug interactions of Caffeine and Abilify, by gender? *:

female:

Craniocerebral injury (injury to cranium and brain)
Fall
Fear
Head injury
Migraine (headache)
Muscle spasms (muscle contraction)
Psychotic disorder
Restless legs syndrome (a powerful urge to move your legs)
Skin injury
Synovial cyst (cyst of joint filled with synovial fluid)

male:

Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Neuropathy peripheral (surface nerve damage)
Lentigo (a small pigmented spot on the skin with a clearly-defined edge, surrounded by normal-appearing skin)
Lumbar radiculopathy (radicular pain in the low back and legs)
Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Polyp
Rectal haemorrhage (bleeding from anus)
Telangiectasia (small dilated blood vessels near the surface of the skin)
Asthma

What are the common drug interactions of Caffeine and Abilify, by age (0-1 to 60+)? *:

0-1:

Maternal exposure during pregnancy (use of substance during pregnancy)
Speech disorder developmental

2-9:

n/a

10-19:

Aggression
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)

20-29:

Abnormal behaviour
Cough
Fall
Injection site pain
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral swelling
Psychotic disorder
Secretion discharge
Tardive dyskinesia (a disorder that involves involuntary movements)

30-39:

Nausea (feeling of having an urge to vomit)
Nervousness
Overdose
Restless legs syndrome (a powerful urge to move your legs)
Suicidal ideation
Urinary tract infection
Arthralgia (joint pain)
Synovial cyst (cyst of joint filled with synovial fluid)
Tardive dyskinesia (a disorder that involves involuntary movements)
Weight increased

40-49:

Asthma
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Back injury
Blood cholesterol increased
Brain injury
Burning mouth syndrome (pain in the mouth and burning sensation on tongue)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Dyspnoea (difficult or laboured respiration)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hypertension (high blood pressure)

50-59:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Disturbance in attention
Dysgraphia (impaired ability to learn to write)
Dystonia (abnormal muscle tone)
Fall
Head injury
Neuropathy peripheral (surface nerve damage)
Psoriasis (immune-mediated disease that affects the skin)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Acute myocardial infarction (acute heart attack)

60+:

Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances)
Blood caffeine increased
Drug hypersensitivity
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 58 people, 61.70%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 14 people, 14.89%
Drowsiness: 7 people, 7.45%
Burning Mouth Syndrome (pain in the mouth and burning sensation on tongue): 6 people, 6.38%
Stress And Anxiety: 5 people, 5.32%
Pain: 5 people, 5.32%
Migraine (headache): 5 people, 5.32%

* Approximation only. Some reports may have incomplete information.

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