Cambia and Metformin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cambia (diclofenac potassium) and Metformin (metformin hydrochloride). Common drug interactions include hypersensitivity among females and hernia among males.

The phase IV clinical study analyzes what interactions people have when they take Cambia and Metformin. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Cambia?

Cambia has active ingredients of diclofenac potassium. eHealthMe is studying from 2,339 Cambia users. Check the latest studies of Cambia.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

On Jul, 08, 2026

72 people who take Cambia and Metformin together, and have interactions are studied.

What are the common drug interactions of Cambia and Metformin, by gender? *:

female:

Hypersensitivity
Infusion site swelling
Intervertebral disc disorder (spinal disc disorder)
Memory impairment
Migraine (headache)
Neck pain
Nerve injury
Pruritus (severe itching of the skin)
Restless legs syndrome (a powerful urge to move your legs)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)

male:

Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Malaise (a feeling of general discomfort or uneasiness)
Erythema nodosum (skin inflammation that results in reddish, painful, tender lumps most commonly located in the front of the legs below)
Pyoderma gangrenosum (ulcerating condition of skin that results in heaped borders with a typical appearance)
Drug ineffective
Pyrexia (fever)
Vomiting
Adjustment disorder with depressed mood
Colonoscopy
Cough

What are the common drug interactions of Cambia and Metformin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Eosinophil count increased
Head injury
Hereditary angioedema (recurrent episodes of severe swelling)
Hunger
Memory impairment
Nausea (feeling of having an urge to vomit)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight increased

30-39:

Fatigue (feeling of tiredness)
Food poisoning (poison in food)
Gastrointestinal infection (infection of stomach and intestine)
Headache (pain in head)
Myalgia (muscle pain)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)
Otitis media (inflammation of the middle ear)
Pain
Poor venous access

40-49:

Hypertension (high blood pressure)
Rosacea (a skin condition that causes facial redness)
Activities of daily living impaired
Drug ineffective
Headache (pain in head)
Peripheral swelling
Pityriasis lichenoides et varioliformis acuta (disease is characterized by rashes and small lesions on the skin)
Vomiting

50-59:

Obstructive airways disorder (a progressive disease that makes it hard to breathe)
Oesophageal spasm (contraction of oesophagus)
Osteomyelitis (infection of bone)
Post-traumatic stress disorder
Pulmonary hypertension (increase in blood pressure in the lung artery)
Renal artery stenosis (narrowing of renal artery)
Serum sickness (hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)

60+:

Sinusitis (inflammation of sinus)
Dyspnoea (difficult or laboured respiration)
Lower respiratory tract infection
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Obstructive airways disorder (a progressive disease that makes it hard to breathe)
Pain in extremity
Panic attack
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonia
Swelling face

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 17 people, 23.61%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 15.28%
Migraine (headache): 10 people, 13.89%
Pain: 8 people, 11.11%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 9.72%
High Blood Pressure: 6 people, 8.33%
Depression: 6 people, 8.33%
Stiff Person Syndrome: 5 people, 6.94%
Drowsiness: 5 people, 6.94%
Asthma: 5 people, 6.94%

* Approximation only. Some reports may have incomplete information.

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