Cambia and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cambia (diclofenac potassium) and Methotrexate (methotrexate sodium). Common drug interactions include contusion among females and diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Cambia and Methotrexate. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Cambia?

Cambia has active ingredients of diclofenac potassium. eHealthMe is studying from 2,339 Cambia users. Check the latest studies of Cambia.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 11, 2026

80 people who take Cambia and Methotrexate together, and have interactions are studied.

Cambia and Methotrexate drug interactions.

What are the common drug interactions of Cambia and Methotrexate, by gender? *:

female:

Contusion (a type of hematoma of tissue in which capillaries)
Grip strength decreased
Joint swelling
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Spinal stenosis (narrowing of spinal column)
Tenderness (pain or discomfort when an affected area is touched)
Pain
Fall
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)

male:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Erythema nodosum (skin inflammation that results in reddish, painful, tender lumps most commonly located in the front of the legs below)
Pyoderma gangrenosum (ulcerating condition of skin that results in heaped borders with a typical appearance)
Pyrexia (fever)
Vomiting
Migraine (headache)
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)

What are the common drug interactions of Cambia and Methotrexate, by age (0-1 to 60+)? *:

0-1:

Contusion (a type of hematoma of tissue in which capillaries)
Grip strength decreased
Joint swelling
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Spinal stenosis (narrowing of spinal column)
Tenderness (pain or discomfort when an affected area is touched)

2-9:

n/a

10-19:

n/a

20-29:

Drug ineffective
Pain

30-39:

n/a

40-49:

Arthralgia (joint pain)
Abdominal discomfort
Alopecia (absence of hair from areas of the body)
Anti-cyclic citrullinated peptide antibody positive
Arthropathy
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)
Discomfort
Drug ineffective

50-59:

Nasopharyngitis (inflammation of the nasopharynx)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Malaise (a feeling of general discomfort or uneasiness)
Productive cough
Sepsis (a severe blood infection that can lead to organ failure and death)
Sputum discoloured
Decreased immune responsiveness
Immune system disorder
Arthralgia (joint pain)

60+:

Contusion (a type of hematoma of tissue in which capillaries)
Grip strength decreased
Rotator cuff repair
Joint swelling
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Spinal stenosis (narrowing of spinal column)
Tenderness (pain or discomfort when an affected area is touched)
Fall
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 18 people, 22.50%
Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 7.50%
Ankylosing Spondylitis (type of arthritis affecting the spine): 5 people, 6.25%
Migraine (headache): 4 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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