Cannabis sativa and Simvastatin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cannabis sativa (marijuana) and Simvastatin (simvastatin). Common drug interactions include injection site pruritus among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Cannabis sativa and Simvastatin. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Cannabis sativa?

Cannabis sativa has active ingredients of marijuana. eHealthMe is studying from 8,631 Cannabis sativa users. Check the latest studies of Cannabis sativa.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.

On Aug, 01, 2026

52 people who take Cannabis sativa and Simvastatin together, and have interactions are studied.

Cannabis sativa and Simvastatin drug interactions.

What are the common drug interactions of Cannabis Sativa and Simvastatin, by gender? *:

female:

Injection site pruritus (severe itching at injection site)
Nasopharyngitis (inflammation of the nasopharynx)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Tooth infection
Burning sensation
Ear infection
Feeling hot
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)

male:

Anxiety
Pain
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Carotid artery disease
Constipation
Depression
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Dysstasia (difficulty in standing)
Erectile dysfunction

What are the common drug interactions of Cannabis Sativa and Simvastatin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abscess limb (limb infection)
Anxiety
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Groin abscess (pus in groin)
Impetigo (contagious skin infection)
Nerve injury
Neuromuscular blockade
Overdose
Pain

40-49:

Dyspnoea (difficult or laboured respiration)
Pain in extremity
Skin discolouration (change of skin colour)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Depression
Emotional distress
Gait disturbance

50-59:

Insomnia (sleeplessness)
Irritability
Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
Nausea (feeling of having an urge to vomit)
Neck pain
Oropharyngeal pain
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Periorbital oedema (swelling around the eyes)
Pyrexia (fever)

60+:

Hallucination (an experience involving the perception of something not present)
Dizziness
Negative thoughts
Pneumonia
Suicidal ideation
Urinary tract infection
Arthralgia (joint pain)
Balance disorder
Blood immunoglobulin g decreased
Confusional state

What are the existing conditions these people have? *

Ovarian Cancer (cancer of ovary): 7 people, 13.46%
Immunodeficiency Common Variable: 7 people, 13.46%
Hiv Infection: 5 people, 9.62%
Primary Immunodeficiency Syndrome: 4 people, 7.69%
High Blood Pressure: 4 people, 7.69%
Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 3 people, 5.77%
Pain: 3 people, 5.77%
Hallucinations (sensations that appear real but are created by your mind): 3 people, 5.77%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 5.77%
Delusion (a false belief or opinion): 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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