Capoten and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Capoten (captopril) and Zoloft (sertraline hydrochloride). Common drug interactions include coronary artery disease among females and coma among males.

The phase IV clinical study analyzes what interactions people have when they take Capoten and Zoloft. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Capoten?

Capoten has active ingredients of captopril. It is often used in high blood pressure. eHealthMe is studying from 2,954 Capoten users. Check the latest studies of Capoten.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

On Jul, 20, 2026

72 people who take Capoten and Zoloft together, and have interactions are studied.

What are the common drug interactions of Capoten and Zoloft, by gender? *:

female:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Decreased appetite
Diabetes mellitus inadequate control
Erythema (redness of the skin)
Fluid retention (an abnormal accumulation of fluid in the blood)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Urinary tract infection
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)

male:

Coma (state of unconsciousness lasting more than six hours)
Confusion
Dyspnoea exertional (breathlessness or shortness of breath)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Multi-organ failure (multisystem organ failure)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Blood creatinine increased
Blood urea increased
Ammonia increased
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

What are the common drug interactions of Capoten and Zoloft, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Sedation
Asthenia (weakness)
Coma (state of unconsciousness lasting more than six hours)
Confusion
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspepsia (indigestion)
Headache (pain in head)
Insomnia (sleeplessness)
Thinking abnormal
Weight increased

40-49:

Renal failure chronic (long lasting kidney dysfunction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Dyspnoea (difficult or laboured respiration)
Injury
Vomiting
Abdominal pain
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)
Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
Arthralgia (joint pain)
Asthma

50-59:

Bacteraemia (presence of bacteria in the blood)
Bladder prolapse (bulging of one or more of the pelvic organs into the vagina)
Blood glucose increased
Blood urea increased
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiac failure congestive
Cardiac valve disease (heart valve disease)
Cardiac ventricular disorder (ventricular dysfunction of heart)
Cardiomegaly (increased size of heart than normal)
Cardiomyopathy (weakening of the heart muscle)

60+:

Hypotension (abnormally low blood pressure)
Cardiomegaly (increased size of heart than normal)
Hepatorenal failure (decrease in kidney function in a person with a severe liver disorder)
Blood creatinine increased
Blood urea increased
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Multi-organ failure (multisystem organ failure)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)

What are the existing conditions these people have? *

Stress And Anxiety: 6 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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