Capsaicin and Metformin drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Capsaicin (capsicum) and Metformin (metformin hydrochloride). Common drug interactions include lower respiratory tract infection among females and drug-induced liver injury among males.
The phase IV clinical study analyzes what interactions people have when they take Capsaicin and Metformin. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.
What is Capsaicin?
Capsaicin has active ingredients of capsicum. eHealthMe is studying from 568 Capsaicin users. Check the latest studies of Capsaicin.
What is Metformin?
Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.
26 people who take Capsaicin and Metformin together, and have interactions are studied.

What are the common drug interactions of Capsaicin and Metformin, by gender? *:
female:
- Lower respiratory tract infection
- Rash
- Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
- Abdominal pain
- Abdominal pain upper
- Abnormal faeces (abnormal stool)
- Constipation
- Diarrhoea
- Erythema (redness of the skin)
- Erythema nodosum (skin inflammation that results in reddish, painful, tender lumps most commonly located in the front of the legs below)
male:
- Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
- Agitation (state of anxiety or nervous excitement)
- Back pain
- Blood glucose increased
- Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
- Delirium (wild excitement)
- Hypoglycaemia (deficiency of glucose in the bloodstream)
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally)
- Neutropenia (an abnormally low number of neutrophils)
What are the common drug interactions of Capsaicin and Metformin, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
- Hypoaesthesia (reduced sense of touch or sensation)
- Impaired healing
- Memory impairment
- Neuropathy peripheral (surface nerve damage)
- Peroneal nerve palsy
- Skin lesion
- Abdominal pain
- Abdominal pain upper
- Abnormal faeces (abnormal stool)
- Constipation
60+:
- Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
- Lower respiratory tract infection
- Erythema nodosum (skin inflammation that results in reddish, painful, tender lumps most commonly located in the front of the legs below)
- Fall
- Neutropenia (an abnormally low number of neutrophils)
- Pain
- White blood cell count decreased
- Rash
- Bronchitis chemical (inflammation of the mucous membrane in the bronchial tubes due to chemical inhalation)
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
What are the existing conditions these people have? *
- High Blood Cholesterol: 7 people, 26.92%
- High Blood Pressure: 6 people, 23.08%
- Hepatocellular Carcinoma (liver cancer): 6 people, 23.08%
- Asthma: 4 people, 15.38%
- Depression: 4 people, 15.38%
- Pain: 4 people, 15.38%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 15.38%
- Muscle Spasms (muscle contraction): 3 people, 11.54%
- Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 3 people, 11.54%
- Eye Disorder: 2 people, 7.69%
* Approximation only. Some reports may have incomplete information.
Do you take Capsaicin and Metformin?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Capsaicin and Metformin:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Capsaicin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Metformin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Capsaicin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Metformin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
- Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
- Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
- T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
- Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
- Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on capsicum and metformin hydrochloride (the active ingredients of Capsaicin and Metformin, respectively), and Capsaicin and Metformin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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