Cardene and Zantac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cardene (nicardipine hydrochloride) and Zantac (ranitidine hydrochloride). Common drug interactions include blood pressure decreased among females and haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Cardene and Zantac. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Cardene?

Cardene has active ingredients of nicardipine hydrochloride. eHealthMe is studying from 729 Cardene users. Check the latest studies of Cardene.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 434,161 Zantac users. Check the latest studies of Zantac.

On Jul, 24, 2026

29 people who take Cardene and Zantac together, and have interactions are studied.

What are the common drug interactions of Cardene and Zantac, by gender? *:

female:

Blood pressure decreased
Dizziness
Excoriation (to tear or wear off the skin of)
Fall
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Weight increased
Blood pressure increased
Breast enlargement
Epistaxis (bleed from the nose)
Fluid retention (an abnormal accumulation of fluid in the blood)

male:

Haemorrhage (bleeding)
Haemorrhage intracranial (bleeding within the skull)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diaphragmatic paralysis (acquired dysfunction of the phrenic nerve)
Endocarditis (inflammation in heart muscle)
Fatigue (feeling of tiredness)
Laryngomalacia (a congenital softening of the tissues of the larynx)
Pericardial effusion (fluid around the heart)
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)

What are the common drug interactions of Cardene and Zantac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Endocarditis (inflammation in heart muscle)
Fatigue (feeling of tiredness)
Laryngomalacia (a congenital softening of the tissues of the larynx)
Pericardial effusion (fluid around the heart)
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Respiratory distress (difficulty in breathing)
Respiratory tract oedema (swelling of respiratory tract due to excess fluid collection in tissue)
Streptococcal bacteraemia (a bacterial infection of blood)

20-29:

n/a

30-39:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Breast enlargement
Menstruation irregular
Pelvic pain
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

40-49:

n/a

50-59:

Dizziness
Excoriation (to tear or wear off the skin of)
Fall
Heart rate decreased
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Respiratory disorder (respiratory disease)
Sweating increased (excess sweating)
Adverse event
Anaesthetic complication
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

60+:

Haemorrhage (bleeding)
Haemorrhage intracranial (bleeding within the skull)
Weight increased
Abdominal pain upper
Anxiety
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic valve incompetence
Asthma
Atelectasis (partial or complete collapse of the lung)

What are the existing conditions these people have? *

Metastases To Central Nervous System (cancer spreads to central nervous system): 5 people, 17.24%
Malignant Melanoma (skin cancer rises from melancytes): 5 people, 17.24%
Pain: 4 people, 13.79%
High Blood Pressure: 4 people, 13.79%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 4 people, 13.79%
Hypersensitivity: 3 people, 10.34%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 10.34%
Depression: 3 people, 10.34%
Cough: 3 people, 10.34%
Sleep Disorder: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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