Carvedilol and Protamine sulfate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Carvedilol (carvedilol) and Protamine sulfate (protamine sulfate). Common drug interactions include death among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Carvedilol and Protamine sulfate. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Carvedilol?

Carvedilol has active ingredients of carvedilol. It is often used in high blood pressure. eHealthMe is studying from 112,649 Carvedilol users. Check the latest studies of Carvedilol.

What is Protamine sulfate?

Protamine sulfate has active ingredients of protamine sulfate. eHealthMe is studying from 3,292 Protamine sulfate users. Check the latest studies of Protamine sulfate.

On Jul, 16, 2026

40 people who take Carvedilol and Protamine sulfate together, and have interactions are studied.

Carvedilol and Protamine sulfate drug interactions.

What are the common drug interactions of Carvedilol and Protamine Sulfate, by gender? *:

female:

Death
Multi-organ failure (multisystem organ failure)
Emotional distress
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)
Stress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Depression
Atelectasis (partial or complete collapse of the lung)
Blood pressure systolic decreased

male:

Renal failure (kidney dysfunction)
Injury
Hypotension (abnormally low blood pressure)
Coagulation factor deficiency (lack of clotting substance in blood)
Haemorrhage (bleeding)
Heparin-induced thrombocytopenia
Depression
Decreased appetite
Diarrhoea
Intracardiac thrombus (presence of a circumscribed mass with heart wall)

What are the common drug interactions of Carvedilol and Protamine Sulfate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Emotional distress
Injury
Pain
Renal failure (kidney dysfunction)
Renal failure acute (rapid kidney dysfunction)

50-59:

Constipation
Fatigue (feeling of tiredness)
Gastritis (inflammation of stomach)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gout (uric acid crystals building up in the body)
Haemodynamic instability (disturbances in the blood movement in our body)
Leukocytosis (increased white blood cells)
Nephrolithiasis (calculi in the kidneys)
Pain in jaw
Pulmonary embolism (blockage of the main artery of the lung)

60+:

Anxiety
Pain
Ventricular extrasystoles (premature cardiac contraction)
Death
Multi-organ failure (multisystem organ failure)
Blood pressure decreased
Cholecystitis acute (rapid infection of gallbladder)
Pulmonary oedema (fluid accumulation in the lungs)
Urethral haemorrhage (urethral bleeding)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)

What are the existing conditions these people have? *

Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 5 people, 12.50%
Pain: 5 people, 12.50%
Constipation: 5 people, 12.50%
Vasodilatation (widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls): 4 people, 10.00%
Blood Uric Acid Abnormal: 4 people, 10.00%
Bradycardia (abnormally slow heart action): 4 people, 10.00%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 4 people, 10.00%
Dehydration (dryness resulting from the removal of water): 4 people, 10.00%
Headache (pain in head): 4 people, 10.00%
Heart Attack: 4 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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