Casodex and Zestril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Casodex (bicalutamide) and Zestril (lisinopril). Common drug interactions include osteonecrosis among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Casodex and Zestril. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Casodex?

Casodex has active ingredients of bicalutamide. It is often used in prostate cancer. eHealthMe is studying from 10,725 Casodex users. Check the latest studies of Casodex.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

On Jul, 10, 2026

60 people who take Casodex and Zestril together, and have interactions are studied.

What are the common drug interactions of Casodex and Zestril, by gender? *:

female:

Osteonecrosis (death of bone)

male:

Dyspnoea (difficult or laboured respiration)
Pain
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Discomfort
Dyspepsia (indigestion)
Dysphagia (a condition in which swallowing is difficult or painful)
Emotional distress
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

What are the common drug interactions of Casodex and Zestril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chest tightness
Dyspnoea (difficult or laboured respiration)
Hypoaesthesia (reduced sense of touch or sensation)
Nausea (feeling of having an urge to vomit)
Prothrombin time ratio decreased
Tachypnoea (a condition of rapid breathing over 20 per minute)
Heart rate increased
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Atrial tachycardia (rhythm disturbance that arises in the atria)
Blood potassium decreased

50-59:

Dehydration (dryness resulting from the removal of water)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Pancreatitis (inflammation of pancreas)
Renal failure (kidney dysfunction)
Small intestinal obstruction (blockage in small intestine)

60+:

Confusional state
Agitation (state of anxiety or nervous excitement)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Atrioventricular block first degree (heart block first degree)
Cardiac flutter (abnormal heart rhythm)
Cardiomegaly (increased size of heart than normal)
Completed suicide (act of taking one's own life)
Death
Dementia (madness)
Depression

What are the existing conditions these people have? *

Neoplasm Malignant (cancer tumour): 13 people, 21.67%
Arrhythmias (irregular heartbeat): 5 people, 8.33%
Metastases To Bone (cancer spreads to bone): 4 people, 6.67%
Pain: 3 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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