Cefotaxime and Methotrexate sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cefotaxime (cefotaxime sodium) and Methotrexate sodium (methotrexate sodium). Common drug interactions include death among females and aplastic anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Cefotaxime and Methotrexate sodium. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Cefotaxime?

Cefotaxime has active ingredients of cefotaxime sodium. eHealthMe is studying from 7,559 Cefotaxime users. Check the latest studies of Cefotaxime.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 97,680 Methotrexate sodium users. Check the latest studies of Methotrexate sodium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

16 people who take Cefotaxime and Methotrexate sodium together, and have interactions are studied.

Cefotaxime and Methotrexate sodium drug interactions.

What are the common drug interactions of Cefotaxime and Methotrexate Sodium, by gender? *:

female:

Death
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Device related infection
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphonia (speech disorder attributable to a disorder of phonation)
Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
Erythema (redness of the skin)
Facial palsy (paralysis of face nerve)
Gait festinating
Mouth ulceration (mouth ulcers)

male:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Drug ineffective
Pulmonary hypertension (increase in blood pressure in the lung artery)
Restrictive cardiomyopathy (a condition in which the walls of the lower chambers of the heart (the ventricles) are abnormally rigid and lack the flexibility)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

What are the common drug interactions of Cefotaxime and Methotrexate Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Pulmonary hypertension (increase in blood pressure in the lung artery)
Restrictive cardiomyopathy (a condition in which the walls of the lower chambers of the heart (the ventricles) are abnormally rigid and lack the flexibility)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

10-19:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphonia (speech disorder attributable to a disorder of phonation)
Facial palsy (paralysis of face nerve)
Gait festinating
Muscle contractions involuntary (uncontrolled muscle contraction)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Quadriplegia (a four limb paralysis)
Respiratory distress (difficulty in breathing)
Tongue disorder (disease of tongue)

20-29:

Sepsis (a severe blood infection that can lead to organ failure and death)

30-39:

Cardiac failure
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

40-49:

Drug ineffective

50-59:

Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Erythema (redness of the skin)
Thrombocytopenia (decrease of platelets in blood)

60+:

Death
Device related infection
Thrombocytopenia (decrease of platelets in blood)
Mouth ulceration (mouth ulcers)
Mucosal haemorrhage (bleeding from mucous membrane)
Neutropenia (an abnormally low number of neutrophils)
Pancreatitis acute (sudden inflammation of pancreas)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Respiratory distress (difficulty in breathing)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the existing conditions these people have? *

Pain: 5 people, 31.25%
Vitamin D Decreased: 3 people, 18.75%
Headache (pain in head): 3 people, 18.75%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3 people, 18.75%
Breast Cancer: 3 people, 18.75%
Breast Cancer Metastatic: 3 people, 18.75%
Constipation: 3 people, 18.75%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 3 people, 18.75%
Epigastric Discomfort: 3 people, 18.75%
Fever: 3 people, 18.75%

* Approximation only. Some reports may have incomplete information.

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